Human serum albumin and immunoglobulin on Dracunculus medinensis

Paul Bloch*, Mette Lund, Birgitte J. Vennervald, Paul E. Simonsen

*Corresponding author af dette arbejde
1 Citationer (Scopus)

Abstract

Dracunculus medinensis recovered from infected humans were examined for the occurrence and localization of human serum albumin and immunoglobulins. Immunoelectrophoretic examination of homogenates prepared from adult female worms (ADGW) and first stage larvae (LVGW) showed that anti-human albumin antibodies reacted to both stages of the parasite. By direct fluorescence antibody technique, antigens resembling human albumin and human immunoglobulins (isotype IgG) were identified on the surface of adult female worms. The occurrence of host-like compounds on the parasites may be an adaptation for survival of the parasites. A possible interference of these compounds should be considered in attempts to develop methods for immunological diagnosis of D. medinensis infections. Copyright (C) 1999 Elsevier Science B.V.

OriginalsprogEngelsk
TidsskriftActa Tropica
Vol/bind73
Udgave nummer2
Sider (fra-til)135-141
Antal sider7
ISSN0001-706X
DOI
StatusUdgivet - 30 jul. 1999
Udgivet eksterntJa

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