Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Human Papillomavirus Testing in the Last Cervical Screening Round at Age 60-64 Years

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Human Papillomavirus Genotypes From Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Risk of Adverse Pregnancy Outcome After Paternal Exposure to Methotrexate Within 90 Days Before Pregnancy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Breech and induction. Time for evidence-based informed consent

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Histological outcomes in HPV-screened elderly women in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Nonalcoholic Fatty Liver Disease Impairs the Liver-Alpha Cell Axis Independent of Hepatic Inflammation and Fibrosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Human papilloma virus vaccination and its real-life efficacy

    Publikation: Bidrag til tidsskriftLederForskningpeer review

Vis graf over relationer

OBJECTIVE: To compare the real-life screening outcomes after cytology was replaced by human papillomavirus (HPV) testing for women aged 60-64 years.

METHODS: Using the Danish national pathology register, we compared screening outcomes during two consecutive calendar periods, one where women were screened with cytology and one where most women were screened with HPV testing. Our primary outcomes were the proportions of women with positive test results, high-grade cervical intraepithelial neoplasia (CIN 2 or worse), and cervical cancer.

RESULTS: Women screened during the HPV testing period were more likely to have a positive screening test result than were women screened during the cytology period (relative proportion 2.80, 95% CI 2.65-2.96). The detection of CIN 2 or worse was also increased (relative proportion 1.54, 95% CI 1.31-1.80), whereas there was no increase in screen-detected cervical cancer diagnoses (relative proportion 1.27, 95% CI 0.76-2.12). Within the first 4 years after a negative screening test result, including 168,477 woman-years at risk after a negative screen result in the HPV period and 451,421 woman-years after a negative screen result in the cytology period, the risk of a cervical cancer diagnosis was approximately 4 per 100,000 woman-years and was similar for both screening tests (relative risk 0.99, 95% CI 0.41-2.35).

CONCLUSION: Human papillomavirus testing led to more positive screening test results and diagnoses of high-grade CIN lesions. Few women were diagnosed with cervical cancer after a negative screening test result.

OriginalsprogEngelsk
TidsskriftObstetrics and Gynecology
Vol/bind138
Udgave nummer3
Sider (fra-til)389-397
Antal sider9
ISSN0029-7844
DOI
StatusUdgivet - 1 sep. 2021

ID: 66981983