Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis

Cecilie D de la Cour; Cecilie D Sperling; Federica Belmonte; Stina Syrjänen; Susanne K Kjaer

doi:10.1111/odi.13322

Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis

Cecilie D de la Cour, Cecilie D Sperling, Federica Belmonte, Stina Syrjänen, Susanne K Kjaer

34 Citationer (Scopus)

Abstract

OBJECTIVES: We aimed to provide pooled estimates of human papillomavirus (HPV) prevalence in oral potentially malignant disorders (OPMD) and evaluate the impact of presence of epithelial dysplasia.

METHODS: We searched PubMed, Embase, and Cochrane Library databases for studies that examined the prevalence of HPV DNA in OPMD tested by polymerase chain reaction (PCR).

RESULTS: Across 52 eligible studies (2,677 cases), we found an overall pooled HPV prevalence of 22.5% (95% confidence interval [CI] 16.6-29.0). Between-study heterogeneity was 93%. When stratified by subgroup, the pooled HPV prevalence in leukoplakia (1,232 cases) was 20.2% (95% CI 11.2-31.1), lichen planus (767 cases) 23.0% (95% CI 15.0-32.2), oral submucous fibrosis (238 cases) 28.6% (95% CI 23.0-34.5), proliferative verrucous leukoplakia (60 cases) 24.7% (95% CI 1.8-62.0), and OPMD unspecified (377 cases) 25.4% (95% CI 16.2-35.8). Information on presence of epithelial dysplasia was available in 19 studies, and the results did not vary substantially between non-dysplastic and dysplastic samples. HPV16 was the predominant genotype among HPV-positive OPMD cases (48.2%, 95% CI 31.4-65.2).

CONCLUSION: We found a pooled HPV DNA prevalence of 22.5% in OPMD cases with great between-study heterogeneity. The HPV prevalence appeared to be comparable across subgroups and independent of epithelial dysplasia.

Originalsprog	Engelsk
Tidsskrift	Oral Diseases
Vol/bind	27
Udgave nummer	3
Sider (fra-til)	431-438
Antal sider	8
ISSN	1354-523X
DOI	https://doi.org/10.1111/odi.13322
Status	Udgivet - apr. 2021

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10.1111/odi.13322

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@article{2f02e2f9eb6948f4a4cb5f3ab57280f3,

title = "Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis",

abstract = "OBJECTIVES: We aimed to provide pooled estimates of human papillomavirus (HPV) prevalence in oral potentially malignant disorders (OPMD) and evaluate the impact of presence of epithelial dysplasia.METHODS: We searched PubMed, Embase, and Cochrane Library databases for studies that examined the prevalence of HPV DNA in OPMD tested by polymerase chain reaction (PCR).RESULTS: Across 52 eligible studies (2,677 cases), we found an overall pooled HPV prevalence of 22.5% (95% confidence interval [CI] 16.6-29.0). Between-study heterogeneity was 93%. When stratified by subgroup, the pooled HPV prevalence in leukoplakia (1,232 cases) was 20.2% (95% CI 11.2-31.1), lichen planus (767 cases) 23.0% (95% CI 15.0-32.2), oral submucous fibrosis (238 cases) 28.6% (95% CI 23.0-34.5), proliferative verrucous leukoplakia (60 cases) 24.7% (95% CI 1.8-62.0), and OPMD unspecified (377 cases) 25.4% (95% CI 16.2-35.8). Information on presence of epithelial dysplasia was available in 19 studies, and the results did not vary substantially between non-dysplastic and dysplastic samples. HPV16 was the predominant genotype among HPV-positive OPMD cases (48.2%, 95% CI 31.4-65.2).CONCLUSION: We found a pooled HPV DNA prevalence of 22.5% in OPMD cases with great between-study heterogeneity. The HPV prevalence appeared to be comparable across subgroups and independent of epithelial dysplasia.",

keywords = "Alphapapillomavirus, Humans, Leukoplakia, Oral/epidemiology, Papillomaviridae/genetics, Papillomavirus Infections/epidemiology, Prevalence, oral submucous fibrosis, oral pathology, meta-analysis, oral leukoplakia, oral lichen planus, papillomaviridae",

author = "{de la Cour}, {Cecilie D} and Sperling, {Cecilie D} and Federica Belmonte and Stina Syrj{\"a}nen and Kjaer, {Susanne K}",

year = "2021",

month = apr,

doi = "10.1111/odi.13322",

language = "English",

volume = "27",

pages = "431--438",

journal = "Oral Diseases",

issn = "1354-523X",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Human papillomavirus prevalence in oral potentially malignant disorders

T2 - Systematic review and meta-analysis

AU - de la Cour, Cecilie D

AU - Sperling, Cecilie D

AU - Belmonte, Federica

AU - Syrjänen, Stina

AU - Kjaer, Susanne K

PY - 2021/4

Y1 - 2021/4

N2 - OBJECTIVES: We aimed to provide pooled estimates of human papillomavirus (HPV) prevalence in oral potentially malignant disorders (OPMD) and evaluate the impact of presence of epithelial dysplasia.METHODS: We searched PubMed, Embase, and Cochrane Library databases for studies that examined the prevalence of HPV DNA in OPMD tested by polymerase chain reaction (PCR).RESULTS: Across 52 eligible studies (2,677 cases), we found an overall pooled HPV prevalence of 22.5% (95% confidence interval [CI] 16.6-29.0). Between-study heterogeneity was 93%. When stratified by subgroup, the pooled HPV prevalence in leukoplakia (1,232 cases) was 20.2% (95% CI 11.2-31.1), lichen planus (767 cases) 23.0% (95% CI 15.0-32.2), oral submucous fibrosis (238 cases) 28.6% (95% CI 23.0-34.5), proliferative verrucous leukoplakia (60 cases) 24.7% (95% CI 1.8-62.0), and OPMD unspecified (377 cases) 25.4% (95% CI 16.2-35.8). Information on presence of epithelial dysplasia was available in 19 studies, and the results did not vary substantially between non-dysplastic and dysplastic samples. HPV16 was the predominant genotype among HPV-positive OPMD cases (48.2%, 95% CI 31.4-65.2).CONCLUSION: We found a pooled HPV DNA prevalence of 22.5% in OPMD cases with great between-study heterogeneity. The HPV prevalence appeared to be comparable across subgroups and independent of epithelial dysplasia.

AB - OBJECTIVES: We aimed to provide pooled estimates of human papillomavirus (HPV) prevalence in oral potentially malignant disorders (OPMD) and evaluate the impact of presence of epithelial dysplasia.METHODS: We searched PubMed, Embase, and Cochrane Library databases for studies that examined the prevalence of HPV DNA in OPMD tested by polymerase chain reaction (PCR).RESULTS: Across 52 eligible studies (2,677 cases), we found an overall pooled HPV prevalence of 22.5% (95% confidence interval [CI] 16.6-29.0). Between-study heterogeneity was 93%. When stratified by subgroup, the pooled HPV prevalence in leukoplakia (1,232 cases) was 20.2% (95% CI 11.2-31.1), lichen planus (767 cases) 23.0% (95% CI 15.0-32.2), oral submucous fibrosis (238 cases) 28.6% (95% CI 23.0-34.5), proliferative verrucous leukoplakia (60 cases) 24.7% (95% CI 1.8-62.0), and OPMD unspecified (377 cases) 25.4% (95% CI 16.2-35.8). Information on presence of epithelial dysplasia was available in 19 studies, and the results did not vary substantially between non-dysplastic and dysplastic samples. HPV16 was the predominant genotype among HPV-positive OPMD cases (48.2%, 95% CI 31.4-65.2).CONCLUSION: We found a pooled HPV DNA prevalence of 22.5% in OPMD cases with great between-study heterogeneity. The HPV prevalence appeared to be comparable across subgroups and independent of epithelial dysplasia.

KW - Alphapapillomavirus

KW - Humans

KW - Leukoplakia, Oral/epidemiology

KW - Papillomaviridae/genetics

KW - Papillomavirus Infections/epidemiology

KW - Prevalence

KW - oral submucous fibrosis

KW - oral pathology

KW - meta-analysis

KW - oral leukoplakia

KW - oral lichen planus

KW - papillomaviridae

UR - http://www.scopus.com/inward/record.url?scp=85082469417&partnerID=8YFLogxK

U2 - 10.1111/odi.13322

DO - 10.1111/odi.13322

M3 - Review

C2 - 32144837

SN - 1354-523X

VL - 27

SP - 431

EP - 438

JO - Oral Diseases

JF - Oral Diseases

IS - 3

ER -

Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis

Abstract

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