Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats

Pauliina Luoto; Iina Laitinen; Sami Suilamo; Kjell Någren; Anne Roivainen

doi:10.1007/s11307-009-0293-1

Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats

Pauliina Luoto, Iina Laitinen, Sami Suilamo, Kjell Någren, Anne Roivainen

Afdeling for Klinisk Fysiologi og Nuklearmedicin

7 Citationer (Scopus)

Abstract

Carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide ([11C]PK11195) is a peripheral benzodiazepine receptor (PBR) antagonist that is used as a positron emission tomography (PET) radiopharmaceutical for neuroinflammatory imaging. This study was designed to investigate the radiation dosimetry of [11C]PK11195.

Originalsprog	Engelsk
Tidsskrift	Molecular Imaging and Biology
Vol/bind	12
Udgave nummer	4
Sider (fra-til)	435-42
Antal sider	8
ISSN	1536-1632
DOI	https://doi.org/10.1007/s11307-009-0293-1
Status	Udgivet - 1 aug. 2010

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10.1007/s11307-009-0293-1

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Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats. / Luoto, Pauliina; Laitinen, Iina; Suilamo, Sami et al.
I: Molecular Imaging and Biology, Bind 12, Nr. 4, 01.08.2010, s. 435-42.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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AU - Luoto, Pauliina

AU - Laitinen, Iina

AU - Suilamo, Sami

AU - Någren, Kjell

AU - Roivainen, Anne

PY - 2010/8/1

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AB - Carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide ([11C]PK11195) is a peripheral benzodiazepine receptor (PBR) antagonist that is used as a positron emission tomography (PET) radiopharmaceutical for neuroinflammatory imaging. This study was designed to investigate the radiation dosimetry of [11C]PK11195.

U2 - 10.1007/s11307-009-0293-1

DO - 10.1007/s11307-009-0293-1

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SN - 1536-1632

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SP - 435

EP - 442

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

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ER -

Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats

Abstract

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