Human complement component C3: characterization of active C3 S and C3 F, the two common genetic variants

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    Abstract

    The two common genetic variants of human C3, C3 S and C3 F, were purified and characterized by SDS-PAGE, agarose gel electrophoresis, isoelectric focusing and amino acid analysis. The difference in electrophoretic mobility between the two variants was conserved after purification, and by isoelectric focusing of the hemolytically active proteins, pI values of 5.86 and 5.81 were determined for C3 S and C3 F, respectively. Any difference in amino acid composition was too small to be detected by amino acid analysis, and the two proteins had the same molecular weight as determined by SDS-PAGE.

    OriginalsprogEngelsk
    TidsskriftMolecular Immunology
    Vol/bind22
    Udgave nummer8
    Sider (fra-til)1005-8
    Antal sider4
    ISSN0161-5890
    StatusUdgivet - aug. 1985

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