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Human chorionic gonadotropin-positive seminoma patients: A registry compiled by the global germ cell tumor collaborative group (G3)

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Harvard

Seidel, C, Daugaard, G, Nestler, T, Tryakin, A, Fedyanin, M, Fankhauser, C, Hermanns, T, Aparicio, J, Heinzelbecker, J, Paffenholz, P, Heidenreich, A, De Giorgi, U, Cathomas, R, Lorch, A, Fingerhut, A, Gayer, F, Bremmer, F, Giannatempo, P, Necchi, A, Aurilio, G, Casadei, C, Tran, B, Dieckmann, K-P, Brito, M, Ruf, C, Oing, C & Bokemeyer, C 2020, 'Human chorionic gonadotropin-positive seminoma patients: A registry compiled by the global germ cell tumor collaborative group (G3)', European Journal of Cancer, bind 132, s. 127-135. https://doi.org/10.1016/j.ejca.2020.03.022

APA

Seidel, C., Daugaard, G., Nestler, T., Tryakin, A., Fedyanin, M., Fankhauser, C., Hermanns, T., Aparicio, J., Heinzelbecker, J., Paffenholz, P., Heidenreich, A., De Giorgi, U., Cathomas, R., Lorch, A., Fingerhut, A., Gayer, F., Bremmer, F., Giannatempo, P., Necchi, A., ... Bokemeyer, C. (2020). Human chorionic gonadotropin-positive seminoma patients: A registry compiled by the global germ cell tumor collaborative group (G3). European Journal of Cancer, 132, 127-135. https://doi.org/10.1016/j.ejca.2020.03.022

CBE

Seidel C, Daugaard G, Nestler T, Tryakin A, Fedyanin M, Fankhauser C, Hermanns T, Aparicio J, Heinzelbecker J, Paffenholz P, Heidenreich A, De Giorgi U, Cathomas R, Lorch A, Fingerhut A, Gayer F, Bremmer F, Giannatempo P, Necchi A, Aurilio G, Casadei C, Tran B, Dieckmann K-P, Brito M, Ruf C, Oing C, Bokemeyer C. 2020. Human chorionic gonadotropin-positive seminoma patients: A registry compiled by the global germ cell tumor collaborative group (G3). European Journal of Cancer. 132:127-135. https://doi.org/10.1016/j.ejca.2020.03.022

MLA

Vancouver

Author

Seidel, Christoph ; Daugaard, Gedske ; Nestler, Tim ; Tryakin, Alexey ; Fedyanin, Mikhail ; Fankhauser, Christian ; Hermanns, Thomas ; Aparicio, Jorge ; Heinzelbecker, Julia ; Paffenholz, Pia ; Heidenreich, Axel ; De Giorgi, Ugo ; Cathomas, Richard ; Lorch, Anja ; Fingerhut, Anna ; Gayer, Fabian ; Bremmer, Felix ; Giannatempo, Patrizia ; Necchi, Andrea ; Aurilio, Gaetano ; Casadei, Chiara ; Tran, Ben ; Dieckmann, Klaus-Peter ; Brito, Margarida ; Ruf, Christian ; Oing, Christoph ; Bokemeyer, Carsten. / Human chorionic gonadotropin-positive seminoma patients : A registry compiled by the global germ cell tumor collaborative group (G3). I: European Journal of Cancer. 2020 ; Bind 132. s. 127-135.

Bibtex

@article{25fe1e6d601c49a6b1c3ef1c1e12f84b,
title = "Human chorionic gonadotropin-positive seminoma patients: A registry compiled by the global germ cell tumor collaborative group (G3)",
abstract = "BACKGROUND: The prognostic role of human chorionic gonadotropin (hCG) and lactate dehydrogenase (LDH) serum levels in seminoma patients remains uncertain. This observational study evaluates the prognostic impact of tumour marker levels, and other clinicopathological findings, in hCG-positive seminoma patients.METHODS: Seminoma patients with serum hCG levels above normal at first diagnosis were eligible for recruitment. Statistical analysis, including multivariate regression, was performed to identify risk factors. Primary end-points were overall survival (OS) and recurrence-free survival (RFS).RESULTS: We recruited 1031 hCG-positive patients (stage I: n = 586; stage II + III: n = 427) diagnosed between 1981 and 2018. In metastatic disease, LDH levels ≥3 above upper normal limit (UNL) pre- (n = 109) or post-orchiectomy (n = 73) and patients aged ≥40 years (n = 187) were associated with poor prognosis: 5-year OS rates of 84% (LDH ≥3 UNL pre-orchiectomy) versus 92% (<3 UNL pre-orchiectomy) (hazard ratio [HR]: 3.155, [95% confidence interval {CI}: 1.28-7.75], P = 0.012), 82% (≥3 UNL post-orchiectomy) versus 92% (<3 UNL post-orchiectomy) (HR: 6.877, [95% CI: 1.61-29.34]; P = 0.009) and 86% (≥40 years) versus 91% (<40 years) (HR: 6.870, [95% CI: 1.45-13.37], P = 0.009), respectively. A subset of patients with hCG levels ≥2000 IU/l pre-orchiectomy (n = 17) exhibited a poor prognosis, with 5-year OS rates of 73% (≥2000 IU/l) versus 94% (<2000 IU/l) (HR: 3.936, [95% CI: 1.02-12.61], P = 0.047).CONCLUSIONS: Age and LDH levels are significantly associated with poor prognosis in hCG-positive seminoma patients. A small number of patients, with levels of hCG ≥2000 IU/l, may represent a separate prognostic subgroup associated with impaired survival rates.",
keywords = "Adult, Chorionic Gonadotropin/metabolism, Follow-Up Studies, Humans, Male, Neoplasms, Germ Cell and Embryonal/metabolism, Orchiectomy/mortality, Prognosis, Registries/statistics & numerical data, Retrospective Studies, Seminoma/metabolism, Survival Rate, Testicular Neoplasms/metabolism, Lactate dehydrogenase, Beta-hCG, Seminoma, Human chorionic gonadotropin, Prognostic factor",
author = "Christoph Seidel and Gedske Daugaard and Tim Nestler and Alexey Tryakin and Mikhail Fedyanin and Christian Fankhauser and Thomas Hermanns and Jorge Aparicio and Julia Heinzelbecker and Pia Paffenholz and Axel Heidenreich and {De Giorgi}, Ugo and Richard Cathomas and Anja Lorch and Anna Fingerhut and Fabian Gayer and Felix Bremmer and Patrizia Giannatempo and Andrea Necchi and Gaetano Aurilio and Chiara Casadei and Ben Tran and Klaus-Peter Dieckmann and Margarida Brito and Christian Ruf and Christoph Oing and Carsten Bokemeyer",
note = "Copyright {\textcopyright} 2020 Elsevier Ltd. All rights reserved.",
year = "2020",
month = jun,
doi = "10.1016/j.ejca.2020.03.022",
language = "English",
volume = "132",
pages = "127--135",
journal = "European Journal of Cancer, Supplement",
issn = "0959-8049",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - Human chorionic gonadotropin-positive seminoma patients

T2 - A registry compiled by the global germ cell tumor collaborative group (G3)

AU - Seidel, Christoph

AU - Daugaard, Gedske

AU - Nestler, Tim

AU - Tryakin, Alexey

AU - Fedyanin, Mikhail

AU - Fankhauser, Christian

AU - Hermanns, Thomas

AU - Aparicio, Jorge

AU - Heinzelbecker, Julia

AU - Paffenholz, Pia

AU - Heidenreich, Axel

AU - De Giorgi, Ugo

AU - Cathomas, Richard

AU - Lorch, Anja

AU - Fingerhut, Anna

AU - Gayer, Fabian

AU - Bremmer, Felix

AU - Giannatempo, Patrizia

AU - Necchi, Andrea

AU - Aurilio, Gaetano

AU - Casadei, Chiara

AU - Tran, Ben

AU - Dieckmann, Klaus-Peter

AU - Brito, Margarida

AU - Ruf, Christian

AU - Oing, Christoph

AU - Bokemeyer, Carsten

N1 - Copyright © 2020 Elsevier Ltd. All rights reserved.

PY - 2020/6

Y1 - 2020/6

N2 - BACKGROUND: The prognostic role of human chorionic gonadotropin (hCG) and lactate dehydrogenase (LDH) serum levels in seminoma patients remains uncertain. This observational study evaluates the prognostic impact of tumour marker levels, and other clinicopathological findings, in hCG-positive seminoma patients.METHODS: Seminoma patients with serum hCG levels above normal at first diagnosis were eligible for recruitment. Statistical analysis, including multivariate regression, was performed to identify risk factors. Primary end-points were overall survival (OS) and recurrence-free survival (RFS).RESULTS: We recruited 1031 hCG-positive patients (stage I: n = 586; stage II + III: n = 427) diagnosed between 1981 and 2018. In metastatic disease, LDH levels ≥3 above upper normal limit (UNL) pre- (n = 109) or post-orchiectomy (n = 73) and patients aged ≥40 years (n = 187) were associated with poor prognosis: 5-year OS rates of 84% (LDH ≥3 UNL pre-orchiectomy) versus 92% (<3 UNL pre-orchiectomy) (hazard ratio [HR]: 3.155, [95% confidence interval {CI}: 1.28-7.75], P = 0.012), 82% (≥3 UNL post-orchiectomy) versus 92% (<3 UNL post-orchiectomy) (HR: 6.877, [95% CI: 1.61-29.34]; P = 0.009) and 86% (≥40 years) versus 91% (<40 years) (HR: 6.870, [95% CI: 1.45-13.37], P = 0.009), respectively. A subset of patients with hCG levels ≥2000 IU/l pre-orchiectomy (n = 17) exhibited a poor prognosis, with 5-year OS rates of 73% (≥2000 IU/l) versus 94% (<2000 IU/l) (HR: 3.936, [95% CI: 1.02-12.61], P = 0.047).CONCLUSIONS: Age and LDH levels are significantly associated with poor prognosis in hCG-positive seminoma patients. A small number of patients, with levels of hCG ≥2000 IU/l, may represent a separate prognostic subgroup associated with impaired survival rates.

AB - BACKGROUND: The prognostic role of human chorionic gonadotropin (hCG) and lactate dehydrogenase (LDH) serum levels in seminoma patients remains uncertain. This observational study evaluates the prognostic impact of tumour marker levels, and other clinicopathological findings, in hCG-positive seminoma patients.METHODS: Seminoma patients with serum hCG levels above normal at first diagnosis were eligible for recruitment. Statistical analysis, including multivariate regression, was performed to identify risk factors. Primary end-points were overall survival (OS) and recurrence-free survival (RFS).RESULTS: We recruited 1031 hCG-positive patients (stage I: n = 586; stage II + III: n = 427) diagnosed between 1981 and 2018. In metastatic disease, LDH levels ≥3 above upper normal limit (UNL) pre- (n = 109) or post-orchiectomy (n = 73) and patients aged ≥40 years (n = 187) were associated with poor prognosis: 5-year OS rates of 84% (LDH ≥3 UNL pre-orchiectomy) versus 92% (<3 UNL pre-orchiectomy) (hazard ratio [HR]: 3.155, [95% confidence interval {CI}: 1.28-7.75], P = 0.012), 82% (≥3 UNL post-orchiectomy) versus 92% (<3 UNL post-orchiectomy) (HR: 6.877, [95% CI: 1.61-29.34]; P = 0.009) and 86% (≥40 years) versus 91% (<40 years) (HR: 6.870, [95% CI: 1.45-13.37], P = 0.009), respectively. A subset of patients with hCG levels ≥2000 IU/l pre-orchiectomy (n = 17) exhibited a poor prognosis, with 5-year OS rates of 73% (≥2000 IU/l) versus 94% (<2000 IU/l) (HR: 3.936, [95% CI: 1.02-12.61], P = 0.047).CONCLUSIONS: Age and LDH levels are significantly associated with poor prognosis in hCG-positive seminoma patients. A small number of patients, with levels of hCG ≥2000 IU/l, may represent a separate prognostic subgroup associated with impaired survival rates.

KW - Adult

KW - Chorionic Gonadotropin/metabolism

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Neoplasms, Germ Cell and Embryonal/metabolism

KW - Orchiectomy/mortality

KW - Prognosis

KW - Registries/statistics & numerical data

KW - Retrospective Studies

KW - Seminoma/metabolism

KW - Survival Rate

KW - Testicular Neoplasms/metabolism

KW - Lactate dehydrogenase

KW - Beta-hCG

KW - Seminoma

KW - Human chorionic gonadotropin

KW - Prognostic factor

UR - http://www.scopus.com/inward/record.url?scp=85083775871&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2020.03.022

DO - 10.1016/j.ejca.2020.03.022

M3 - Journal article

C2 - 32361383

VL - 132

SP - 127

EP - 135

JO - European Journal of Cancer, Supplement

JF - European Journal of Cancer, Supplement

SN - 0959-8049

ER -

ID: 61373004