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Region Hovedstaden - en del af Københavns Universitetshospital
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Human adipogenesis is associated with genome-wide DNA methylation and gene-expression changes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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AIM: To define the genomic distribution and function of DNA methylation changes during human adipogenesis.

METHODS: We isolated adipocyte-derived stem cells from 13 individuals and analyzed genome-wide DNA methylation and gene expression in cultured adipocyte-derived stem cells and mature adipocytes.

RESULTS: We observed altered DNA methylation of 11,947 CpG sites and altered expression of 11,830 transcripts after differentiation. De novo methylation was observed across all genomic elements. Co-existence of genes with both altered expression and DNA methylation was found in genes important for cell cycle and adipokine signaling.

CONCLUSION: Human adipogenesis is associated with significant DNA methylation changes across the entire genome and may impact regulation of cell cycle and adipokine signaling.

OriginalsprogEngelsk
TidsskriftEpigenomics
Vol/bind8
Udgave nummer12
Sider (fra-til)1601-1617
Antal sider17
ISSN1750-1911
DOI
StatusUdgivet - dec. 2016

ID: 49913935