How does electroconvulsive therapy work? Theories on its mechanism

Tom G Bolwig

    131 Citationer (Scopus)

    Abstract

    This article reviews 3 current theories of electroconvulsive therapy (ECT). One theory points to generalized seizures as essential for the therapeutic efficacy of ECT. Another theory highlights the normalization of neuroendocrine dysfunction in melancholic depression as a result of ECT. A third theory is based on recent findings of increased hippocampal neurogenesis and synaptogenesis in experimental animals given electroconvulsive seizures. Presently, the endocrine theory has the strongest foundation to explain the working mechanism of ECT.
    OriginalsprogEngelsk
    TidsskriftCanadian Journal of Psychiatry
    Vol/bind56
    Udgave nummer1
    Sider (fra-til)13-8
    Antal sider6
    ISSN0706-7437
    StatusUdgivet - 2011

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