Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

Signe Sørensen Torekov; L Ma; Niels Grarup; B Hartmann; I A Hainerová; Urd Kielgast; Hannelouise Kissow; M Rosenkilde; J Lebl; Daniel Rinse Witte; T Jørgensen; A Sandbaek; Torsten Lauritzen; O D Madsen; J Wang; A Linneberg; S Madsbad; J J Holst; T Hansen; O Pedersen; GIANT Consortium

doi:10.1007/s00125-011-2265-7

Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

Signe Sørensen Torekov, L Ma, Niels Grarup, B Hartmann, I A Hainerová, Urd Kielgast, Hannelouise Kissow, M Rosenkilde, J Lebl, Daniel Rinse Witte, T Jørgensen, A Sandbaek, Torsten Lauritzen, O D Madsen, J Wang, A Linneberg, S Madsbad, J J Holst, T Hansen, O PedersenGIANT Consortium

Endokrinologisk Forskningsenhed AHH

16 Citationer (Scopus)

Abstract

The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/or related metabolic traits.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	54
Udgave nummer	11
Sider (fra-til)	2820-31
Antal sider	12
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-011-2265-7
Status	Udgivet - 2011

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Torekov, S. S., Ma, L., Grarup, N., Hartmann, B., Hainerová, I. A., Kielgast, U., Kissow, H., Rosenkilde, M., Lebl, J., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Madsen, O. D., Wang, J., Linneberg, A., Madsbad, S., Holst, J. J., Hansen, T., ... GIANT Consortium (2011). Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1. Diabetologia, 54(11), 2820-31. https://doi.org/10.1007/s00125-011-2265-7

Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1. / Torekov, Signe Sørensen; Ma, L; Grarup, Niels et al.
I: Diabetologia, Bind 54, Nr. 11, 2011, s. 2820-31.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Torekov, SS, Ma, L, Grarup, N, Hartmann, B, Hainerová, IA, Kielgast, U, Kissow, H, Rosenkilde, M, Lebl, J, Witte, DR, Jørgensen, T, Sandbaek, A, Lauritzen, T, Madsen, OD, Wang, J, Linneberg, A , Madsbad, S, Holst, JJ, Hansen, T, Pedersen, O & GIANT Consortium 2011, 'Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1', Diabetologia, bind 54, nr. 11, s. 2820-31. https://doi.org/10.1007/s00125-011-2265-7

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title = "Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1",

abstract = "The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/or related metabolic traits.",

keywords = "Adolescent, Adult, Age of Onset, Aged, Case-Control Studies, Child, Child, Preschool, Czechoslovakia, Denmark, Diabetes Mellitus, Type 2, Europe, Female, Genetic Association Studies, Glucagon, Glucagon-Like Peptide 1, Homozygote, Humans, Infant, Insulin, Insulin Resistance, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide",

author = "Torekov, \{Signe S{\o}rensen\} and L Ma and Niels Grarup and B Hartmann and Hainerov{\'a}, \{I A\} and Urd Kielgast and Hannelouise Kissow and M Rosenkilde and J Lebl and Witte, \{Daniel Rinse\} and T J{\o}rgensen and A Sandbaek and Torsten Lauritzen and Madsen, \{O D\} and J Wang and A Linneberg and S Madsbad and Holst, \{J J\} and T Hansen and O Pedersen and \{GIANT Consortium\}",

year = "2011",

doi = "10.1007/s00125-011-2265-7",

language = "English",

volume = "54",

pages = "2820--31",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Science and Business Media Deutschland GmbH",

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TY - JOUR

T1 - Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

AU - Torekov, Signe Sørensen

AU - Ma, L

AU - Grarup, Niels

AU - Hartmann, B

AU - Hainerová, I A

AU - Kielgast, Urd

AU - Kissow, Hannelouise

AU - Rosenkilde, M

AU - Lebl, J

AU - Witte, Daniel Rinse

AU - Jørgensen, T

AU - Sandbaek, A

AU - Lauritzen, Torsten

AU - Madsen, O D

AU - Wang, J

AU - Linneberg, A

AU - Madsbad, S

AU - Holst, J J

AU - Hansen, T

AU - Pedersen, O

AU - GIANT Consortium

PY - 2011

Y1 - 2011

N2 - The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/or related metabolic traits.

AB - The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/or related metabolic traits.

KW - Adolescent

KW - Adult

KW - Age of Onset

KW - Aged

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Czechoslovakia

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Europe

KW - Female

KW - Genetic Association Studies

KW - Glucagon

KW - Glucagon-Like Peptide 1

KW - Homozygote

KW - Humans

KW - Infant

KW - Insulin

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Obesity

KW - Polymorphism, Single Nucleotide

UR - https://www.scopus.com/pages/publications/80054713602

U2 - 10.1007/s00125-011-2265-7

DO - 10.1007/s00125-011-2265-7

M3 - Journal article

C2 - 21822931

SN - 0012-186X

VL - 54

SP - 2820

EP - 2831

JO - Diabetologia

JF - Diabetologia

IS - 11

ER -

Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

Abstract

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