Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease

Hreinn Stefansson; G Bragi Walters; Gardar Sveinbjornsson; Vinicius Tragante; Gudmundur Einarsson; Hannes Helgason; Asgeir Sigurðsson; Doruk Beyter; Audunn S Snaebjarnarson; Erna V Ivarsdottir; Gudmar Thorleifsson; Bjarni V Halldorsson; Gudmundur Norddahl; Unnur Styrkarsdottir; Arni Sturluson; Hilma Holm; Agnar Helgason; Kristjan Moore; Hannes P Eggertsson; Asmundur H Oddsson; Gudrun A Jonsdottir; Arni F Gunnarsson; Gyda Bjornsdottir; Rosa S Gisladottir; Thorgeir E Thorgeirsson; Astros Skuladottir; Daniel F Gudbjartsson; Patrick Sulem; Palmi Jonsson; Steinunn Thordardottir; Jon Snaedal; Helga Eyjolfsdottir; Byron Creese; Clive Ballard; Anne Corbett; Miguel Vasconcelos Da Silva; Dag Aarsland; Ole A Andreassen; Thomas Werge; Karina Banasik; Søren Brunak; Henrik Ullum; Ruth Frikke-Schmidt; Sisse R Ostrowski; Maria Didriksen; Erik Sørensen; Anja H Simonsen; Jørgen E Nielsen; Gunhild Waldemar; Ole B Pedersen; DemGen Study Group

doi:10.1056/NEJMc2314334

Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease

Hreinn Stefansson^*
, G Bragi Walters
, Gardar Sveinbjornsson
, Vinicius Tragante
, Gudmundur Einarsson
, Hannes Helgason
, Asgeir Sigurðsson
, Doruk Beyter
, Audunn S Snaebjarnarson
, Erna V Ivarsdottir
, Gudmar Thorleifsson
, Bjarni V Halldorsson
, Gudmundur Norddahl
, Unnur Styrkarsdottir
, Arni Sturluson
, Hilma Holm
, Agnar Helgason
, Kristjan Moore
, Hannes P Eggertsson
, Asmundur H Oddsson

Gudrun A Jonsdottir, Arni F Gunnarsson, Gyda Bjornsdottir, Rosa S Gisladottir, Thorgeir E Thorgeirsson, Astros Skuladottir, Daniel F Gudbjartsson, Patrick Sulem, Palmi Jonsson, Steinunn Thordardottir, Jon Snaedal, Helga Eyjolfsdottir, Byron Creese, Clive Ballard, Anne Corbett, Miguel Vasconcelos Da Silva, Dag Aarsland, Ole A Andreassen, Thomas Werge, Karina Banasik, Søren Brunak, Henrik Ullum, Ruth Frikke-Schmidt, Sisse R Ostrowski, Maria Didriksen, Erik Sørensen, Anja H Simonsen, Jørgen E Nielsen, Gunhild Waldemar, Ole B Pedersen, DemGen Study Group

^*Corresponding author af dette arbejde

12 Citationer (Scopus)

Originalsprog	Engelsk
Tidsskrift	The New England journal of medicine
Vol/bind	390
Udgave nummer	23
Sider (fra-til)	2217-2219
Antal sider	3
ISSN	0028-4793
DOI	https://doi.org/10.1056/NEJMc2314334
Status	Udgivet - 20 jun. 2024

Adgang til dokumentet

10.1056/NEJMc2314334

Andre filer og links

Link to publication in Scopus

Citationsformater

Stefansson, H., Walters, G. B., Sveinbjornsson, G., Tragante, V., Einarsson, G., Helgason, H., Sigurðsson, A., Beyter, D., Snaebjarnarson, A. S., Ivarsdottir, E. V., Thorleifsson, G., Halldorsson, B. V., Norddahl, G., Styrkarsdottir, U., Sturluson, A., Holm, H., Helgason, A., Moore, K., Eggertsson, H. P., ... DemGen Study Group (2024). Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease. The New England journal of medicine, 390(23), 2217-2219. https://doi.org/10.1056/NEJMc2314334

Stefansson, H, Walters, GB, Sveinbjornsson, G, Tragante, V, Einarsson, G, Helgason, H, Sigurðsson, A, Beyter, D, Snaebjarnarson, AS, Ivarsdottir, EV, Thorleifsson, G, Halldorsson, BV, Norddahl, G, Styrkarsdottir, U, Sturluson, A, Holm, H, Helgason, A, Moore, K, Eggertsson, HP, Oddsson, AH, Jonsdottir, GA, Gunnarsson, AF, Bjornsdottir, G, Gisladottir, RS, Thorgeirsson, TE, Skuladottir, A, Gudbjartsson, DF, Sulem, P, Jonsson, P, Thordardottir, S, Snaedal, J, Eyjolfsdottir, H, Creese, B, Ballard, C, Corbett, A, Vasconcelos Da Silva, M, Aarsland, D, Andreassen, OA, Werge, T , Banasik, K, Brunak, S, Ullum, H, Frikke-Schmidt, R , Ostrowski, SR , Didriksen, M , Sørensen, E , Simonsen, AH , Nielsen, JE , Waldemar, G, Pedersen, OB & DemGen Study Group 2024, 'Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease', The New England journal of medicine, bind 390, nr. 23, s. 2217-2219. https://doi.org/10.1056/NEJMc2314334

@article{a88d718c09db455a9a8ce99a2798340e,

title = "Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease",

keywords = "Humans, Alzheimer Disease/genetics, Receptors, Immunologic/genetics, Membrane Glycoproteins/genetics, Homozygote, Genetic Predisposition to Disease, Aged, Female, Male",

author = "Hreinn Stefansson and Walters, \{G Bragi\} and Gardar Sveinbjornsson and Vinicius Tragante and Gudmundur Einarsson and Hannes Helgason and Asgeir Sigur{\dh}sson and Doruk Beyter and Snaebjarnarson, \{Audunn S\} and Ivarsdottir, \{Erna V\} and Gudmar Thorleifsson and Halldorsson, \{Bjarni V\} and Gudmundur Norddahl and Unnur Styrkarsdottir and Arni Sturluson and Hilma Holm and Agnar Helgason and Kristjan Moore and Eggertsson, \{Hannes P\} and Oddsson, \{Asmundur H\} and Jonsdottir, \{Gudrun A\} and Gunnarsson, \{Arni F\} and Gyda Bjornsdottir and Gisladottir, \{Rosa S\} and Thorgeirsson, \{Thorgeir E\} and Astros Skuladottir and Gudbjartsson, \{Daniel F\} and Patrick Sulem and Palmi Jonsson and Steinunn Thordardottir and Jon Snaedal and Helga Eyjolfsdottir and Byron Creese and Clive Ballard and Anne Corbett and \{Vasconcelos Da Silva\}, Miguel and Dag Aarsland and Andreassen, \{Ole A\} and Thomas Werge and Karina Banasik and S{\o}ren Brunak and Henrik Ullum and Ruth Frikke-Schmidt and Ostrowski, \{Sisse R\} and Maria Didriksen and Erik S{\o}rensen and Simonsen, \{Anja H\} and Nielsen, \{J{\o}rgen E\} and Gunhild Waldemar and Pedersen, \{Ole B\} and \{DemGen Study Group\}",

year = "2024",

month = jun,

day = "20",

doi = "10.1056/NEJMc2314334",

language = "English",

volume = "390",

pages = "2217--2219",

journal = "The New England journal of medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "23",

}

TY - JOUR

T1 - Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease

AU - Stefansson, Hreinn

AU - Walters, G Bragi

AU - Sveinbjornsson, Gardar

AU - Tragante, Vinicius

AU - Einarsson, Gudmundur

AU - Helgason, Hannes

AU - Sigurðsson, Asgeir

AU - Beyter, Doruk

AU - Snaebjarnarson, Audunn S

AU - Ivarsdottir, Erna V

AU - Thorleifsson, Gudmar

AU - Halldorsson, Bjarni V

AU - Norddahl, Gudmundur

AU - Styrkarsdottir, Unnur

AU - Sturluson, Arni

AU - Holm, Hilma

AU - Helgason, Agnar

AU - Moore, Kristjan

AU - Eggertsson, Hannes P

AU - Oddsson, Asmundur H

AU - Jonsdottir, Gudrun A

AU - Gunnarsson, Arni F

AU - Bjornsdottir, Gyda

AU - Gisladottir, Rosa S

AU - Thorgeirsson, Thorgeir E

AU - Skuladottir, Astros

AU - Gudbjartsson, Daniel F

AU - Sulem, Patrick

AU - Jonsson, Palmi

AU - Thordardottir, Steinunn

AU - Snaedal, Jon

AU - Eyjolfsdottir, Helga

AU - Creese, Byron

AU - Ballard, Clive

AU - Corbett, Anne

AU - Vasconcelos Da Silva, Miguel

AU - Aarsland, Dag

AU - Andreassen, Ole A

AU - Werge, Thomas

AU - Banasik, Karina

AU - Brunak, Søren

AU - Ullum, Henrik

AU - Frikke-Schmidt, Ruth

AU - Ostrowski, Sisse R

AU - Didriksen, Maria

AU - Sørensen, Erik

AU - Simonsen, Anja H

AU - Nielsen, Jørgen E

AU - Waldemar, Gunhild

AU - Pedersen, Ole B

AU - DemGen Study Group

PY - 2024/6/20

Y1 - 2024/6/20

KW - Humans

KW - Alzheimer Disease/genetics

KW - Receptors, Immunologic/genetics

KW - Membrane Glycoproteins/genetics

KW - Homozygote

KW - Genetic Predisposition to Disease

KW - Aged

KW - Female

KW - Male

UR - https://www.scopus.com/pages/publications/85196684137

U2 - 10.1056/NEJMc2314334

DO - 10.1056/NEJMc2314334

M3 - Comment/debate

C2 - 38899702

SN - 0028-4793

VL - 390

SP - 2217

EP - 2219

JO - The New England journal of medicine

JF - The New England journal of medicine

IS - 23

ER -