Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias

Robert Clarke; Derrick A Bennett; Sarah Parish; Petra Verhoef; Mariska Dötsch-Klerk; Mark Lathrop; Peng Xu; Børge G Nordestgaard; Hilma Holm; Jemma C Hopewell; Danish Saleheen; Toshihiro Tanaka; Sonia S Anand; John C Chambers; Marcus E Kleber; Willem H Ouwehand; Yoshiji Yamada; Clara Elbers; Bas Peters; Alexandre F R Stewart; Muredach M Reilly; Barbara Thorand; Salim Yusuf; James C Engert; Themistocles L Assimes; Jaspal Kooner; John Danesh; Hugh Watkins; Nilesh J Samani; Rory Collins; Richard Peto; MTHFR Studies Collaborative Group

doi:10.1371/journal.pmed.1001177

Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias

Robert Clarke, Derrick A Bennett, Sarah Parish, Petra Verhoef, Mariska Dötsch-Klerk, Mark Lathrop, Peng Xu, Børge G Nordestgaard, Hilma Holm, Jemma C Hopewell, Danish Saleheen, Toshihiro Tanaka, Sonia S Anand, John C Chambers, Marcus E Kleber, Willem H Ouwehand, Yoshiji Yamada, Clara Elbers, Bas Peters, Alexandre F R StewartMuredach M Reilly, Barbara Thorand, Salim Yusuf, James C Engert, Themistocles L Assimes, Jaspal Kooner, John Danesh, Hugh Watkins, Nilesh J Samani, Rory Collins, Richard Peto, MTHFR Studies Collaborative Group

172 Citationer (Scopus)

Abstract

Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality.

Originalsprog	Engelsk
Tidsskrift	PLOS Medicine
Vol/bind	9
Udgave nummer	2
Sider (fra-til)	e1001177
ISSN	1549-1676
DOI	https://doi.org/10.1371/journal.pmed.1001177
Status	Udgivet - 2012

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10.1371/journal.pmed.1001177

Citationsformater

Clarke, R., Bennett, D. A., Parish, S., Verhoef, P., Dötsch-Klerk, M., Lathrop, M., Xu, P., Nordestgaard, B. G., Holm, H., Hopewell, J. C., Saleheen, D., Tanaka, T., Anand, S. S., Chambers, J. C., Kleber, M. E., Ouwehand, W. H., Yamada, Y., Elbers, C., Peters, B., ... MTHFR Studies Collaborative Group (2012). Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLOS Medicine, 9(2), e1001177. https://doi.org/10.1371/journal.pmed.1001177

Clarke, R, Bennett, DA, Parish, S, Verhoef, P, Dötsch-Klerk, M, Lathrop, M, Xu, P, Nordestgaard, BG, Holm, H, Hopewell, JC, Saleheen, D, Tanaka, T, Anand, SS, Chambers, JC, Kleber, ME, Ouwehand, WH, Yamada, Y, Elbers, C, Peters, B, Stewart, AFR, Reilly, MM, Thorand, B, Yusuf, S, Engert, JC, Assimes, TL, Kooner, J, Danesh, J, Watkins, H, Samani, NJ, Collins, R, Peto, R & MTHFR Studies Collaborative Group 2012, 'Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias', PLOS Medicine, bind 9, nr. 2, s. e1001177. https://doi.org/10.1371/journal.pmed.1001177

@article{7986083daa4747a38bdf185955c7b0f2,

title = "Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias",

abstract = "Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so {"}Mendelian randomization{"} studies using this variant as an instrumental variable could help test causality.",

keywords = "Bias (Epidemiology), Coronary Disease, Folic Acid, Genotype, Homocysteine, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Polymorphism, Genetic, Risk Factors",

author = "Robert Clarke and Bennett, {Derrick A} and Sarah Parish and Petra Verhoef and Mariska D{\"o}tsch-Klerk and Mark Lathrop and Peng Xu and Nordestgaard, {B{\o}rge G} and Hilma Holm and Hopewell, {Jemma C} and Danish Saleheen and Toshihiro Tanaka and Anand, {Sonia S} and Chambers, {John C} and Kleber, {Marcus E} and Ouwehand, {Willem H} and Yoshiji Yamada and Clara Elbers and Bas Peters and Stewart, {Alexandre F R} and Reilly, {Muredach M} and Barbara Thorand and Salim Yusuf and Engert, {James C} and Assimes, {Themistocles L} and Jaspal Kooner and John Danesh and Hugh Watkins and Samani, {Nilesh J} and Rory Collins and Richard Peto and {MTHFR Studies Collaborative Group}",

year = "2012",

doi = "10.1371/journal.pmed.1001177",

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T1 - Homocysteine and coronary heart disease

T2 - meta-analysis of MTHFR case-control studies, avoiding publication bias

AU - Clarke, Robert

AU - Bennett, Derrick A

AU - Parish, Sarah

AU - Verhoef, Petra

AU - Dötsch-Klerk, Mariska

AU - Lathrop, Mark

AU - Xu, Peng

AU - Nordestgaard, Børge G

AU - Holm, Hilma

AU - Hopewell, Jemma C

AU - Saleheen, Danish

AU - Tanaka, Toshihiro

AU - Anand, Sonia S

AU - Chambers, John C

AU - Kleber, Marcus E

AU - Ouwehand, Willem H

AU - Yamada, Yoshiji

AU - Elbers, Clara

AU - Peters, Bas

AU - Stewart, Alexandre F R

AU - Reilly, Muredach M

AU - Thorand, Barbara

AU - Yusuf, Salim

AU - Engert, James C

AU - Assimes, Themistocles L

AU - Kooner, Jaspal

AU - Danesh, John

AU - Watkins, Hugh

AU - Samani, Nilesh J

AU - Collins, Rory

AU - Peto, Richard

AU - MTHFR Studies Collaborative Group

PY - 2012

Y1 - 2012

N2 - Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality.

AB - Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality.

KW - Bias (Epidemiology)

KW - Coronary Disease

KW - Folic Acid

KW - Genotype

KW - Homocysteine

KW - Humans

KW - Methylenetetrahydrofolate Reductase (NADPH2)

KW - Polymorphism, Genetic

KW - Risk Factors

U2 - 10.1371/journal.pmed.1001177

DO - 10.1371/journal.pmed.1001177

M3 - Journal article

C2 - 22363213

SN - 1549-1676

VL - 9

SP - e1001177

JO - PLOS Medicine

JF - PLOS Medicine

IS - 2

ER -

Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias

Abstract

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