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Histological outcomes in HPV-screened elderly women in Denmark

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Harvard

St-Martin, G, Viborg, PH, Andersen, ABT, Andersen, B, Christensen, J, Ejersbo, D, Heje, HN, Jochumsen, KM, Johansen, T, Larsen, LG, Lynge, E, Serizawa, RR & Waldstrøm, M 2021, 'Histological outcomes in HPV-screened elderly women in Denmark', PLoS One, bind 16, nr. 2, e0246902, s. 1-12. https://doi.org/10.1371/journal.pone.0246902

APA

St-Martin, G., Viborg, P. H., Andersen, A. B. T., Andersen, B., Christensen, J., Ejersbo, D., Heje, H. N., Jochumsen, K. M., Johansen, T., Larsen, L. G., Lynge, E., Serizawa, R. R., & Waldstrøm, M. (2021). Histological outcomes in HPV-screened elderly women in Denmark. PLoS One, 16(2), 1-12. [e0246902]. https://doi.org/10.1371/journal.pone.0246902

CBE

St-Martin G, Viborg PH, Andersen ABT, Andersen B, Christensen J, Ejersbo D, Heje HN, Jochumsen KM, Johansen T, Larsen LG, Lynge E, Serizawa RR, Waldstrøm M. 2021. Histological outcomes in HPV-screened elderly women in Denmark. PLoS One. 16(2):1-12. https://doi.org/10.1371/journal.pone.0246902

MLA

Vancouver

St-Martin G, Viborg PH, Andersen ABT, Andersen B, Christensen J, Ejersbo D o.a. Histological outcomes in HPV-screened elderly women in Denmark. PLoS One. 2021 feb 11;16(2):1-12. e0246902. https://doi.org/10.1371/journal.pone.0246902

Author

St-Martin, Gry ; Viborg, Petra Hall ; Andersen, Ane Birgitte Telén ; Andersen, Berit ; Christensen, Jette ; Ejersbo, Dorthe ; Heje, Hanne Nørgaard ; Jochumsen, Kirsten Marie ; Johansen, Tonje ; Larsen, Lise Grupe ; Lynge, Elsebeth ; Serizawa, Reza Rafiolsadat ; Waldstrøm, Marianne. / Histological outcomes in HPV-screened elderly women in Denmark. I: PLoS One. 2021 ; Bind 16, Nr. 2. s. 1-12.

Bibtex

@article{0003591b81a1493b8c38e15f7c4c0174,
title = "Histological outcomes in HPV-screened elderly women in Denmark",
abstract = "INTRODUCTION: Danish women exit cervical cancer screening at age 65 years, but 23% of cervical cancer cases occur beyond this age. In addition, due to gradual implementation of cervical cancer screening, older women are underscreened by today´s standards. A one-time screening with HPV test was therefore offered to Danish women born before 1948.METHODS: Register based study reporting histology diagnoses and conizations in women found HPV positive in the one-time screening. Number and proportion of women with severe or non-severe histology results were calculated for screened and HPV-positive women by age group or region of residence. Number of women with biopsy and/or conization per case of cervical intraepithelial neoplasia (CIN) grade 2 or worse (CIN2+) or CIN3+ were also calculated by age groups and region.RESULTS: 4,479 (4.1% of screened women) had positive HPV test. 94% of these had one or more additional tests. 2,785 (62%) of HPV-positive women had histology results, and conization was performed in 1,076 (24% of HPV-positive and 1% of all screened women). HPV positivity and CIN3+ detection varied little between regions, but the proportions of HPV positive women undergoing histology varied between regions from 40% to 86% and the proportion with conization from 13% to 36%. Correspondingly, the number of histologies and conizations per CIN3+ detected varied from 5.9 to 11.2 and 1.8 to 4.7, respectively. In total, 514 CIN2+ (0.47% of screened women, 11% of HPV-positive) and 337 CIN3+ (0.31% of screened women, 7.5% of HPV-positive) were diagnosed, including 37 cervical cancer cases.DISCUSSION: HPV screening of insufficiently screened birth cohorts can potentially prevent morbidity and mortality from cervical cancer but longer follow-up is needed to see if cancer incidence declines in the screened women in the coming years. Management strategies differed among regions which influenced the proportions undergoing biopsy/conization.",
author = "Gry St-Martin and Viborg, {Petra Hall} and Andersen, {Ane Birgitte Tel{\'e}n} and Berit Andersen and Jette Christensen and Dorthe Ejersbo and Heje, {Hanne N{\o}rgaard} and Jochumsen, {Kirsten Marie} and Tonje Johansen and Larsen, {Lise Grupe} and Elsebeth Lynge and Serizawa, {Reza Rafiolsadat} and Marianne Waldstr{\o}m",
note = "Publisher Copyright: {\textcopyright} 2021 St-Martin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
day = "11",
doi = "10.1371/journal.pone.0246902",
language = "English",
volume = "16",
pages = "1--12",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Histological outcomes in HPV-screened elderly women in Denmark

AU - St-Martin, Gry

AU - Viborg, Petra Hall

AU - Andersen, Ane Birgitte Telén

AU - Andersen, Berit

AU - Christensen, Jette

AU - Ejersbo, Dorthe

AU - Heje, Hanne Nørgaard

AU - Jochumsen, Kirsten Marie

AU - Johansen, Tonje

AU - Larsen, Lise Grupe

AU - Lynge, Elsebeth

AU - Serizawa, Reza Rafiolsadat

AU - Waldstrøm, Marianne

N1 - Publisher Copyright: © 2021 St-Martin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2/11

Y1 - 2021/2/11

N2 - INTRODUCTION: Danish women exit cervical cancer screening at age 65 years, but 23% of cervical cancer cases occur beyond this age. In addition, due to gradual implementation of cervical cancer screening, older women are underscreened by today´s standards. A one-time screening with HPV test was therefore offered to Danish women born before 1948.METHODS: Register based study reporting histology diagnoses and conizations in women found HPV positive in the one-time screening. Number and proportion of women with severe or non-severe histology results were calculated for screened and HPV-positive women by age group or region of residence. Number of women with biopsy and/or conization per case of cervical intraepithelial neoplasia (CIN) grade 2 or worse (CIN2+) or CIN3+ were also calculated by age groups and region.RESULTS: 4,479 (4.1% of screened women) had positive HPV test. 94% of these had one or more additional tests. 2,785 (62%) of HPV-positive women had histology results, and conization was performed in 1,076 (24% of HPV-positive and 1% of all screened women). HPV positivity and CIN3+ detection varied little between regions, but the proportions of HPV positive women undergoing histology varied between regions from 40% to 86% and the proportion with conization from 13% to 36%. Correspondingly, the number of histologies and conizations per CIN3+ detected varied from 5.9 to 11.2 and 1.8 to 4.7, respectively. In total, 514 CIN2+ (0.47% of screened women, 11% of HPV-positive) and 337 CIN3+ (0.31% of screened women, 7.5% of HPV-positive) were diagnosed, including 37 cervical cancer cases.DISCUSSION: HPV screening of insufficiently screened birth cohorts can potentially prevent morbidity and mortality from cervical cancer but longer follow-up is needed to see if cancer incidence declines in the screened women in the coming years. Management strategies differed among regions which influenced the proportions undergoing biopsy/conization.

AB - INTRODUCTION: Danish women exit cervical cancer screening at age 65 years, but 23% of cervical cancer cases occur beyond this age. In addition, due to gradual implementation of cervical cancer screening, older women are underscreened by today´s standards. A one-time screening with HPV test was therefore offered to Danish women born before 1948.METHODS: Register based study reporting histology diagnoses and conizations in women found HPV positive in the one-time screening. Number and proportion of women with severe or non-severe histology results were calculated for screened and HPV-positive women by age group or region of residence. Number of women with biopsy and/or conization per case of cervical intraepithelial neoplasia (CIN) grade 2 or worse (CIN2+) or CIN3+ were also calculated by age groups and region.RESULTS: 4,479 (4.1% of screened women) had positive HPV test. 94% of these had one or more additional tests. 2,785 (62%) of HPV-positive women had histology results, and conization was performed in 1,076 (24% of HPV-positive and 1% of all screened women). HPV positivity and CIN3+ detection varied little between regions, but the proportions of HPV positive women undergoing histology varied between regions from 40% to 86% and the proportion with conization from 13% to 36%. Correspondingly, the number of histologies and conizations per CIN3+ detected varied from 5.9 to 11.2 and 1.8 to 4.7, respectively. In total, 514 CIN2+ (0.47% of screened women, 11% of HPV-positive) and 337 CIN3+ (0.31% of screened women, 7.5% of HPV-positive) were diagnosed, including 37 cervical cancer cases.DISCUSSION: HPV screening of insufficiently screened birth cohorts can potentially prevent morbidity and mortality from cervical cancer but longer follow-up is needed to see if cancer incidence declines in the screened women in the coming years. Management strategies differed among regions which influenced the proportions undergoing biopsy/conization.

UR - http://www.scopus.com/inward/record.url?scp=85101360643&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0246902

DO - 10.1371/journal.pone.0246902

M3 - Journal article

C2 - 33571319

VL - 16

SP - 1

EP - 12

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 2

M1 - e0246902

ER -

ID: 62244063