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Hippocampal Volume, Cognitive Functions, Depression, Anxiety, and Quality of Life in Patients With Cushing Syndrome

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@article{23410f9b75fe493e9edcd8fffa337f52,
title = "Hippocampal Volume, Cognitive Functions, Depression, Anxiety, and Quality of Life in Patients With Cushing Syndrome",
abstract = "CONTEXT: Cushing syndrome (CS) is associated with hippocampal atrophy and psychopathology. OBJECTIVE: The primary objective of this systematic review was to assess hippocampal volume (HV) in patients with CS. The secondary objectives were to assess patients' cognitive functioning, depressive and anxiety symptoms, and quality of life. DATA SOURCES: PubMed, Embase, Cochrane, LILACs, and Scopus databases were searched for relevant studies until 1 May 2019. STUDY SELECTION: Case-control studies comparing patients with CS with healthy control subjects, or studies assessing patients with CS before and after surgery were included. The initial search resulted in 18 studies fulfilling the inclusion criteria. DATA EXTRACTION: Data extraction regarding all outcomes was performed independently by two reviewers. Quality assessment was assessed with the Newcastle-Ottawa Scale for case-control studies. DATA SYNTHESIS: Meta-analysis was performed using a random effect model. The right-side HV in patients with CS was reduced by a standard mean difference of 0.68 (95{\%} CI, -1.12 to -0.24; P = 0.002; I2 = 0{\%}) compared with healthy control subjects, but with no increase in HV after surgery. Patients had more depressive symptoms, impaired cognitive functions, and reduced health-related QoL (HRQoL), which all responded favorably to surgery. The data did not support the presence of anxiety in patients with CS. CONCLUSION: An overall reduction of HV in patients with CS was not suggested by the study findings. However, most cognitive domains were significantly affected and responded favorably to surgery. Depressive symptoms and reduced HRQoL were present in patients with CS and improved after surgery.",
author = "Frimodt-M{\o}ller, {Katrine Emilie} and {M{\o}llegaard Jepsen}, {Jens Richardt} and Ulla Feldt-Rasmussen and Jesper Krogh",
note = "Copyright {\circledC} 2019 Endocrine Society.",
year = "2019",
month = "10",
day = "1",
doi = "10.1210/jc.2019-00749",
language = "English",
volume = "104",
pages = "4563–4577",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",
number = "10",

}

RIS

TY - JOUR

T1 - Hippocampal Volume, Cognitive Functions, Depression, Anxiety, and Quality of Life in Patients With Cushing Syndrome

AU - Frimodt-Møller, Katrine Emilie

AU - Møllegaard Jepsen, Jens Richardt

AU - Feldt-Rasmussen, Ulla

AU - Krogh, Jesper

N1 - Copyright © 2019 Endocrine Society.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - CONTEXT: Cushing syndrome (CS) is associated with hippocampal atrophy and psychopathology. OBJECTIVE: The primary objective of this systematic review was to assess hippocampal volume (HV) in patients with CS. The secondary objectives were to assess patients' cognitive functioning, depressive and anxiety symptoms, and quality of life. DATA SOURCES: PubMed, Embase, Cochrane, LILACs, and Scopus databases were searched for relevant studies until 1 May 2019. STUDY SELECTION: Case-control studies comparing patients with CS with healthy control subjects, or studies assessing patients with CS before and after surgery were included. The initial search resulted in 18 studies fulfilling the inclusion criteria. DATA EXTRACTION: Data extraction regarding all outcomes was performed independently by two reviewers. Quality assessment was assessed with the Newcastle-Ottawa Scale for case-control studies. DATA SYNTHESIS: Meta-analysis was performed using a random effect model. The right-side HV in patients with CS was reduced by a standard mean difference of 0.68 (95% CI, -1.12 to -0.24; P = 0.002; I2 = 0%) compared with healthy control subjects, but with no increase in HV after surgery. Patients had more depressive symptoms, impaired cognitive functions, and reduced health-related QoL (HRQoL), which all responded favorably to surgery. The data did not support the presence of anxiety in patients with CS. CONCLUSION: An overall reduction of HV in patients with CS was not suggested by the study findings. However, most cognitive domains were significantly affected and responded favorably to surgery. Depressive symptoms and reduced HRQoL were present in patients with CS and improved after surgery.

AB - CONTEXT: Cushing syndrome (CS) is associated with hippocampal atrophy and psychopathology. OBJECTIVE: The primary objective of this systematic review was to assess hippocampal volume (HV) in patients with CS. The secondary objectives were to assess patients' cognitive functioning, depressive and anxiety symptoms, and quality of life. DATA SOURCES: PubMed, Embase, Cochrane, LILACs, and Scopus databases were searched for relevant studies until 1 May 2019. STUDY SELECTION: Case-control studies comparing patients with CS with healthy control subjects, or studies assessing patients with CS before and after surgery were included. The initial search resulted in 18 studies fulfilling the inclusion criteria. DATA EXTRACTION: Data extraction regarding all outcomes was performed independently by two reviewers. Quality assessment was assessed with the Newcastle-Ottawa Scale for case-control studies. DATA SYNTHESIS: Meta-analysis was performed using a random effect model. The right-side HV in patients with CS was reduced by a standard mean difference of 0.68 (95% CI, -1.12 to -0.24; P = 0.002; I2 = 0%) compared with healthy control subjects, but with no increase in HV after surgery. Patients had more depressive symptoms, impaired cognitive functions, and reduced health-related QoL (HRQoL), which all responded favorably to surgery. The data did not support the presence of anxiety in patients with CS. CONCLUSION: An overall reduction of HV in patients with CS was not suggested by the study findings. However, most cognitive domains were significantly affected and responded favorably to surgery. Depressive symptoms and reduced HRQoL were present in patients with CS and improved after surgery.

U2 - 10.1210/jc.2019-00749

DO - 10.1210/jc.2019-00749

M3 - Journal article

VL - 104

SP - 4563

EP - 4577

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 10

ER -

ID: 57539940