Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Higher striatal D2-receptor availability in aerobically fit older adults but non-selective intervention effects after aerobic versus resistance training

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Validation of structural brain connectivity networks: The impact of scanning parameters

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Accessibility of cortical regions to focal TES: Dependence on spatial position, safety, and practical constraints

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Disease-informed brain mapping teaches important lessons about the human brain

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  1. Improvement in indices of cellular protection after psychological treatment for social anxiety disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Relationships between Physical Activity, Sedentary Behaviour and Cognitive Functions in Office Workers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Development and Feasibility of a Regulated, Supramaximal High-Intensity Training Program Adapted for Older Individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Copenhagen Consensus statement 2019: physical activity and ageing

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Relationships Between Aerobic Fitness Levels and Cognitive Performance in Swedish Office Workers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

There is much evidence that dopamine is vital for cognitive functioning in aging. Here we tested the hypothesis that aerobic exercise and fitness influence dopaminergic neurotransmission in the striatum, and in turn performance on offline working-memory updating tasks. Dopaminergic neurotransmission was measured by positron emission tomography (PET) and the non-displacable binding potential (BPND) of [11C]raclopride, i.e. dopamine (DA) D2-receptor (D2R) availability. Fifty-four sedentary older adults underwent a six-months exercise intervention, performing either aerobic exercise or stretching, toning, and resistance active control training. At baseline, higher aerobic fitness levels (VO2peak) were associated with higher BPND in the striatum, providing evidence of a link between an objective measure of aerobic fitness and D2R in older adults. BPND decreased substantially over the intervention in both groups but the intervention effects were non-selective with respect to exercise group. The decrease was several times larger than any previously estimated annual decline in D2R, potentially due to increased endogenous DA. Working-memory was unrelated to D2R both at baseline and following the intervention. To conclude, we provide partial evidence for a link between physical exercise and DA. Utilizing a PET protocol able to disentangle both D2R and DA levels could shed further light on whether, and how, aerobic exercise impacts the dopaminergic system in older adults.

OriginalsprogEngelsk
Artikelnummer116044
TidsskriftNeuroImage
Vol/bind202
Sider (fra-til)1-10
Antal sider10
ISSN1053-8119
DOI
StatusUdgivet - 15 nov. 2019

ID: 57713723