Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT

Niels Jacobsen; Tina Frisch; Niels Keiding; Carsten Heilmann; Henrik Sengeløv; Hans O Madsen; Ebbe Dickmeiss; Lars P Ryder

doi:10.1002/jha2.438

Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT

Niels Jacobsen^*, Tina Frisch, Niels Keiding, Carsten Heilmann, Henrik Sengeløv, Hans O Madsen, Ebbe Dickmeiss, Lars P Ryder

^*Corresponding author af dette arbejde

Abstract

The effect of higher FOXP3 mRNA expression by recipient pre-transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50-48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53-1.81]).

Originalsprog	Engelsk
Tidsskrift	EJHaem
Vol/bind	3
Udgave nummer	3
Sider (fra-til)	975-979
Antal sider	5
ISSN	2688-6146
DOI	https://doi.org/10.1002/jha2.438
Status	Udgivet - aug. 2022

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10.1002/jha2.438

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@article{1aac448557c64690b9b37010ff3fbed3,

title = "Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT",

abstract = "The effect of higher FOXP3 mRNA expression by recipient pre-transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50-48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53-1.81]).",

author = "Niels Jacobsen and Tina Frisch and Niels Keiding and Carsten Heilmann and Henrik Sengel{\o}v and Madsen, {Hans O} and Ebbe Dickmeiss and Ryder, {Lars P}",

note = "{\textcopyright} 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.",

year = "2022",

month = aug,

doi = "10.1002/jha2.438",

language = "English",

volume = "3",

pages = "975--979",

journal = "EJHaem",

issn = "2688-6146",

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TY - JOUR

T1 - Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT

AU - Jacobsen, Niels

AU - Frisch, Tina

AU - Keiding, Niels

AU - Heilmann, Carsten

AU - Sengeløv, Henrik

AU - Madsen, Hans O

AU - Dickmeiss, Ebbe

AU - Ryder, Lars P

PY - 2022/8

Y1 - 2022/8

N2 - The effect of higher FOXP3 mRNA expression by recipient pre-transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50-48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53-1.81]).

AB - The effect of higher FOXP3 mRNA expression by recipient pre-transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50-48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53-1.81]).

U2 - 10.1002/jha2.438

DO - 10.1002/jha2.438

M3 - Journal article

C2 - 36051013

SN - 2688-6146

VL - 3

SP - 975

EP - 979

JO - EJHaem

JF - EJHaem

IS - 3

ER -

Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT

Abstract

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