Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Higher habitual flavonoid intakes are associated with a lower risk of peripheral artery disease hospitalizations

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Bondonno, NP, Murray, K, Cassidy, A, Bondonno, CP, Lewis, JR, Croft, KD, Kyrø, C, Gislason, G, Torp-Pedersen, C, Scalbert, A, Tjønneland, A, Hodgson, JM & Dalgaard, F 2021, 'Higher habitual flavonoid intakes are associated with a lower risk of peripheral artery disease hospitalizations', The American journal of clinical nutrition, bind 113, nr. 1, s. 187-199. https://doi.org/10.1093/ajcn/nqaa300

APA

Bondonno, N. P., Murray, K., Cassidy, A., Bondonno, C. P., Lewis, J. R., Croft, K. D., Kyrø, C., Gislason, G., Torp-Pedersen, C., Scalbert, A., Tjønneland, A., Hodgson, J. M., & Dalgaard, F. (2021). Higher habitual flavonoid intakes are associated with a lower risk of peripheral artery disease hospitalizations. The American journal of clinical nutrition, 113(1), 187-199. https://doi.org/10.1093/ajcn/nqaa300

CBE

MLA

Vancouver

Author

Bondonno, Nicola P ; Murray, Kevin ; Cassidy, Aedin ; Bondonno, Catherine P ; Lewis, Joshua R ; Croft, Kevin D ; Kyrø, Cecilie ; Gislason, Gunnar ; Torp-Pedersen, Christian ; Scalbert, Augustin ; Tjønneland, Anne ; Hodgson, Jonathan M ; Dalgaard, Frederik. / Higher habitual flavonoid intakes are associated with a lower risk of peripheral artery disease hospitalizations. I: The American journal of clinical nutrition. 2021 ; Bind 113, Nr. 1. s. 187-199.

Bibtex

@article{356a86c02a694928af591c8f6b0e59ea,
title = "Higher habitual flavonoid intakes are associated with a lower risk of peripheral artery disease hospitalizations",
abstract = "BACKGROUND: The role of nutrition in the primary prevention of peripheral artery disease (PAD), the third leading cause of atherosclerotic cardiovascular disease, is undetermined. Flavonoids may attenuate atherosclerosis and therefore persons who consume flavonoid-rich foods may have a lower risk of developing PAD.OBJECTIVES: We aimed to examine the association between flavonoid intake and PAD hospitalizations and investigate if the association differs according to established risk factors for PAD.METHODS: Baseline data from 55,647 participants of the Danish Diet, Cancer, and Health Study without PAD, recruited from 1993 to 1997, were cross-linked with Danish nationwide registries. Flavonoid intake was calculated from FFQs using the Phenol-Explorer database. Associations were examined using multivariable-adjusted restricted cubic splines based on Cox proportional hazards models.RESULTS: After a median [IQR] follow-up time of 21 [20-22] y, 2131 participants had been hospitalized for any PAD. The association between total flavonoid intake and total PAD hospitalizations was nonlinear, reaching a plateau at ∼750-1000 mg/d. Compared with the median flavonoid intake in quintile 1 (174 mg/d), an intake of 1000 mg/d was associated with a 32% lower risk of any PAD hospitalization (HR: 0.68; 95% CI: 0.60, 0.77), a 26% lower risk of atherosclerosis (HR: 0.74; 95% CI: 0.62, 0.88), a 28% lower risk of an aneurysm (HR: 0.72; 95% CI: 0.59, 0.88), and a 47% lower risk of a hospitalization for other peripheral vascular disease (HR: 0.53; 95% CI: 0.42, 0.67). A higher total flavonoid intake was also significantly associated with a lower incidence of revascularization or endovascular surgery and lower extremity amputation. The association between total flavonoid intake and PAD hospitalizations differed according to baseline smoking status, alcohol intake, BMI, and diabetes status.CONCLUSIONS: Ensuring the adequate consumption of flavonoid-rich foods, particularly in subpopulations prone to the development of atherosclerosis, may be a key strategy to lower the risk of PAD.",
keywords = "cohort study, lifestyle, nutrition, peripheral artery disease, primary prevention, Nutrition, Primary prevention, Cohort study, Peripheral artery disease, Lifestyle",
author = "Bondonno, {Nicola P} and Kevin Murray and Aedin Cassidy and Bondonno, {Catherine P} and Lewis, {Joshua R} and Croft, {Kevin D} and Cecilie Kyr{\o} and Gunnar Gislason and Christian Torp-Pedersen and Augustin Scalbert and Anne Tj{\o}nneland and Hodgson, {Jonathan M} and Frederik Dalgaard",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition.",
year = "2021",
month = jan,
doi = "10.1093/ajcn/nqaa300",
language = "English",
volume = "113",
pages = "187--199",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "1",

}

RIS

TY - JOUR

T1 - Higher habitual flavonoid intakes are associated with a lower risk of peripheral artery disease hospitalizations

AU - Bondonno, Nicola P

AU - Murray, Kevin

AU - Cassidy, Aedin

AU - Bondonno, Catherine P

AU - Lewis, Joshua R

AU - Croft, Kevin D

AU - Kyrø, Cecilie

AU - Gislason, Gunnar

AU - Torp-Pedersen, Christian

AU - Scalbert, Augustin

AU - Tjønneland, Anne

AU - Hodgson, Jonathan M

AU - Dalgaard, Frederik

N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition.

PY - 2021/1

Y1 - 2021/1

N2 - BACKGROUND: The role of nutrition in the primary prevention of peripheral artery disease (PAD), the third leading cause of atherosclerotic cardiovascular disease, is undetermined. Flavonoids may attenuate atherosclerosis and therefore persons who consume flavonoid-rich foods may have a lower risk of developing PAD.OBJECTIVES: We aimed to examine the association between flavonoid intake and PAD hospitalizations and investigate if the association differs according to established risk factors for PAD.METHODS: Baseline data from 55,647 participants of the Danish Diet, Cancer, and Health Study without PAD, recruited from 1993 to 1997, were cross-linked with Danish nationwide registries. Flavonoid intake was calculated from FFQs using the Phenol-Explorer database. Associations were examined using multivariable-adjusted restricted cubic splines based on Cox proportional hazards models.RESULTS: After a median [IQR] follow-up time of 21 [20-22] y, 2131 participants had been hospitalized for any PAD. The association between total flavonoid intake and total PAD hospitalizations was nonlinear, reaching a plateau at ∼750-1000 mg/d. Compared with the median flavonoid intake in quintile 1 (174 mg/d), an intake of 1000 mg/d was associated with a 32% lower risk of any PAD hospitalization (HR: 0.68; 95% CI: 0.60, 0.77), a 26% lower risk of atherosclerosis (HR: 0.74; 95% CI: 0.62, 0.88), a 28% lower risk of an aneurysm (HR: 0.72; 95% CI: 0.59, 0.88), and a 47% lower risk of a hospitalization for other peripheral vascular disease (HR: 0.53; 95% CI: 0.42, 0.67). A higher total flavonoid intake was also significantly associated with a lower incidence of revascularization or endovascular surgery and lower extremity amputation. The association between total flavonoid intake and PAD hospitalizations differed according to baseline smoking status, alcohol intake, BMI, and diabetes status.CONCLUSIONS: Ensuring the adequate consumption of flavonoid-rich foods, particularly in subpopulations prone to the development of atherosclerosis, may be a key strategy to lower the risk of PAD.

AB - BACKGROUND: The role of nutrition in the primary prevention of peripheral artery disease (PAD), the third leading cause of atherosclerotic cardiovascular disease, is undetermined. Flavonoids may attenuate atherosclerosis and therefore persons who consume flavonoid-rich foods may have a lower risk of developing PAD.OBJECTIVES: We aimed to examine the association between flavonoid intake and PAD hospitalizations and investigate if the association differs according to established risk factors for PAD.METHODS: Baseline data from 55,647 participants of the Danish Diet, Cancer, and Health Study without PAD, recruited from 1993 to 1997, were cross-linked with Danish nationwide registries. Flavonoid intake was calculated from FFQs using the Phenol-Explorer database. Associations were examined using multivariable-adjusted restricted cubic splines based on Cox proportional hazards models.RESULTS: After a median [IQR] follow-up time of 21 [20-22] y, 2131 participants had been hospitalized for any PAD. The association between total flavonoid intake and total PAD hospitalizations was nonlinear, reaching a plateau at ∼750-1000 mg/d. Compared with the median flavonoid intake in quintile 1 (174 mg/d), an intake of 1000 mg/d was associated with a 32% lower risk of any PAD hospitalization (HR: 0.68; 95% CI: 0.60, 0.77), a 26% lower risk of atherosclerosis (HR: 0.74; 95% CI: 0.62, 0.88), a 28% lower risk of an aneurysm (HR: 0.72; 95% CI: 0.59, 0.88), and a 47% lower risk of a hospitalization for other peripheral vascular disease (HR: 0.53; 95% CI: 0.42, 0.67). A higher total flavonoid intake was also significantly associated with a lower incidence of revascularization or endovascular surgery and lower extremity amputation. The association between total flavonoid intake and PAD hospitalizations differed according to baseline smoking status, alcohol intake, BMI, and diabetes status.CONCLUSIONS: Ensuring the adequate consumption of flavonoid-rich foods, particularly in subpopulations prone to the development of atherosclerosis, may be a key strategy to lower the risk of PAD.

KW - cohort study

KW - lifestyle

KW - nutrition

KW - peripheral artery disease

KW - primary prevention

KW - Nutrition

KW - Primary prevention

KW - Cohort study

KW - Peripheral artery disease

KW - Lifestyle

UR - http://www.scopus.com/inward/record.url?scp=85100296404&partnerID=8YFLogxK

U2 - 10.1093/ajcn/nqaa300

DO - 10.1093/ajcn/nqaa300

M3 - Journal article

C2 - 33236045

VL - 113

SP - 187

EP - 199

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 1

ER -

ID: 61338602