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High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies

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  • Goda Vaitkevičienė
  • Erik Forestier
  • Marit Hellebostad
  • Mats Heyman
  • Olafur G Jonsson
  • Päivi M Lähteenmäki
  • Susanne Rosthoej
  • Stefan Söderhäll
  • Kjeld Schmiegelow
  • Nordic Society of Paediatric Haematology and Oncology (NOPHO)
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Prognostic impact of peripheral blood white blood cell count (WBC) at the diagnosis of childhood acute lymphoblastic leukaemia (ALL) was evaluated in a population-based consecutive series of 2666 children aged 1-15 treated for ALL between 1992 and 2008 in the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden). Ten-year event-free (pEFS(10 y)) survival and overall (pOS(10 y)) survival were 0.75 ± 0.01 and 0.85 ± 0.01, respectively. Although treatment intensity was determined by WBC, non-remission and relapsed patients still had significantly higher WBC than those in remission for B-cell precursor (BCP) (median WBC: 24.8 vs. 14.0 vs. 8.3 × 10(9) /L, P <0.001), but not for T-lineage (T-ALL) (median WBC: 127.8 vs. 113.0 vs. 86.8 × 10(9) /L, P = 0.22). pEFS was inversely related to WBC for BCP (P <0.001), but not for T-ALL. WBC was not associated with risk of event for BCP or T-ALL for patients with minimal residual disease at the end of induction (MRD(d29) )
OriginalsprogEngelsk
TidsskriftEuropean Journal of Haematology
Vol/bind86
Udgave nummer1
Sider (fra-til)38-46
Antal sider9
ISSN0902-4441
DOI
StatusUdgivet - 2011

ID: 34567875