High-protein induced renal enlargement is growth hormone independent

Johan W van Neck; Vesna Cingel; Arlène K van Vliet; Stenvert L S Drop; Allan Flyvbjerg

doi:10.1111/j.1523-1755.2002.kid584.x

High-protein induced renal enlargement is growth hormone independent

Johan W van Neck, Vesna Cingel, Arlène K van Vliet, Stenvert L S Drop, Allan Flyvbjerg

6 Citationer (Scopus)

Abstract

BACKGROUND: Growth hormone (GH) and insulin-like growth factors (IGFs) have been postulated as pathogenic factors in several forms of renal growth, including that induced by high-protein (HP) diets. Compensatory renal growth (CRG) following renal uninephrectomy is strictly GH dependent, while the exact role of GH as a regulating factor in HP induced renal growth has not been fully clarified.

METHODS: To elucidate a possible direct role for GH in HP-induced renal growth, we examined the effect of a newly developed specific GH-receptor (GHR) antagonist (B2036-PEG) on renal growth and renal GH/IGF-system expression in HP-fed mice.

RESULTS: Mice fed a HP diet (45% protein) for one week demonstrated renal hypertrophy and increased renal IGF-I. GH receptor antagonist (GHRA) treatment neither modified renal IGF-I nor abolished the renal hypertrophy. In contrast, however, GHRA administration did modify renal mRNA expression of many members of the GH and IGF systems.

CONCLUSIONS: The major new finding is that HP-induced renal growth in adult mice is GH independent.

Originalsprog	Engelsk
Tidsskrift	Kidney International
Vol/bind	62
Udgave nummer	4
Sider (fra-til)	1187-95
Antal sider	9
ISSN	0085-2538
DOI	https://doi.org/10.1111/j.1523-1755.2002.kid584.x
Status	Udgivet - okt. 2002
Udgivet eksternt	Ja

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10.1111/j.1523-1755.2002.kid584.x

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title = "High-protein induced renal enlargement is growth hormone independent",

abstract = "BACKGROUND: Growth hormone (GH) and insulin-like growth factors (IGFs) have been postulated as pathogenic factors in several forms of renal growth, including that induced by high-protein (HP) diets. Compensatory renal growth (CRG) following renal uninephrectomy is strictly GH dependent, while the exact role of GH as a regulating factor in HP induced renal growth has not been fully clarified.METHODS: To elucidate a possible direct role for GH in HP-induced renal growth, we examined the effect of a newly developed specific GH-receptor (GHR) antagonist (B2036-PEG) on renal growth and renal GH/IGF-system expression in HP-fed mice.RESULTS: Mice fed a HP diet (45% protein) for one week demonstrated renal hypertrophy and increased renal IGF-I. GH receptor antagonist (GHRA) treatment neither modified renal IGF-I nor abolished the renal hypertrophy. In contrast, however, GHRA administration did modify renal mRNA expression of many members of the GH and IGF systems.CONCLUSIONS: The major new finding is that HP-induced renal growth in adult mice is GH independent.",

keywords = "Animals, Blood Glucose, Body Weight, Dietary Proteins, Eating, Female, Gene Expression, Growth Hormone, Human Growth Hormone, Hypertrophy, Insulin, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor I, Kidney, Liver, Mice, Mice, Inbred BALB C, Organ Size, RNA, Messenger, Journal Article, Research Support, Non-U.S. Gov't",

author = "{van Neck}, {Johan W} and Vesna Cingel and {van Vliet}, {Arl{\`e}ne K} and Drop, {Stenvert L S} and Allan Flyvbjerg",

year = "2002",

month = oct,

doi = "10.1111/j.1523-1755.2002.kid584.x",

language = "English",

volume = "62",

pages = "1187--95",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Elsevier BV",

number = "4",

}

TY - JOUR

T1 - High-protein induced renal enlargement is growth hormone independent

AU - van Neck, Johan W

AU - Cingel, Vesna

AU - van Vliet, Arlène K

AU - Drop, Stenvert L S

AU - Flyvbjerg, Allan

PY - 2002/10

Y1 - 2002/10

N2 - BACKGROUND: Growth hormone (GH) and insulin-like growth factors (IGFs) have been postulated as pathogenic factors in several forms of renal growth, including that induced by high-protein (HP) diets. Compensatory renal growth (CRG) following renal uninephrectomy is strictly GH dependent, while the exact role of GH as a regulating factor in HP induced renal growth has not been fully clarified.METHODS: To elucidate a possible direct role for GH in HP-induced renal growth, we examined the effect of a newly developed specific GH-receptor (GHR) antagonist (B2036-PEG) on renal growth and renal GH/IGF-system expression in HP-fed mice.RESULTS: Mice fed a HP diet (45% protein) for one week demonstrated renal hypertrophy and increased renal IGF-I. GH receptor antagonist (GHRA) treatment neither modified renal IGF-I nor abolished the renal hypertrophy. In contrast, however, GHRA administration did modify renal mRNA expression of many members of the GH and IGF systems.CONCLUSIONS: The major new finding is that HP-induced renal growth in adult mice is GH independent.

AB - BACKGROUND: Growth hormone (GH) and insulin-like growth factors (IGFs) have been postulated as pathogenic factors in several forms of renal growth, including that induced by high-protein (HP) diets. Compensatory renal growth (CRG) following renal uninephrectomy is strictly GH dependent, while the exact role of GH as a regulating factor in HP induced renal growth has not been fully clarified.METHODS: To elucidate a possible direct role for GH in HP-induced renal growth, we examined the effect of a newly developed specific GH-receptor (GHR) antagonist (B2036-PEG) on renal growth and renal GH/IGF-system expression in HP-fed mice.RESULTS: Mice fed a HP diet (45% protein) for one week demonstrated renal hypertrophy and increased renal IGF-I. GH receptor antagonist (GHRA) treatment neither modified renal IGF-I nor abolished the renal hypertrophy. In contrast, however, GHRA administration did modify renal mRNA expression of many members of the GH and IGF systems.CONCLUSIONS: The major new finding is that HP-induced renal growth in adult mice is GH independent.

KW - Animals

KW - Blood Glucose

KW - Body Weight

KW - Dietary Proteins

KW - Eating

KW - Female

KW - Gene Expression

KW - Growth Hormone

KW - Human Growth Hormone

KW - Hypertrophy

KW - Insulin

KW - Insulin-Like Growth Factor Binding Proteins

KW - Insulin-Like Growth Factor I

KW - Kidney

KW - Liver

KW - Mice

KW - Mice, Inbred BALB C

KW - Organ Size

KW - RNA, Messenger

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/j.1523-1755.2002.kid584.x

DO - 10.1111/j.1523-1755.2002.kid584.x

M3 - Journal article

C2 - 12234289

SN - 0085-2538

VL - 62

SP - 1187

EP - 1195

JO - Kidney International

JF - Kidney International

IS - 4

ER -

High-protein induced renal enlargement is growth hormone independent

Abstract

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