Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

High Plasma Levels of Neuropeptide Y Correlate With Good Clinical Outcome But are not Correlated to Cerebral Blood Flow or Vasospasm After Subarachnoid Hemorrhage

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cognitive Functioning After Surgery in Middle-aged and Elderly Danish Twins

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Measuring elevated intracranial pressure through noninvasive methods: a review of the literature

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Osmotherapy in brain edema: a questionable therapy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Common variants of the ACE gene and aneurysmal subarachnoid hemorrhage in a Danish population: a case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND AND PURPOSE: Delayed cerebral ischemia (DCI) is a serious and frequent complication following subarachnoid hemorrhage. Treatments with convincing effect are lacking and the pathophysiology behind DCI remains poorly understood. Neuropeptide Y (NPY) is a potent endogenous vasoconstrictor and a role of NPY in the development of DCI has been proposed. This study investigated the relationship between plasma-NPY and cerebral blood flow (CBF), cerebral vasospasm, DCI, and clinical outcome.

METHODS: In 90 patients with subarachnoid hemorrhage, NPY was measured in peripheral blood days 2 to 11. Any occurrence of DCI was recorded and CBF was quantified day 3 and day 8 using computed tomography (CT) perfusion. CT angiography was performed day 8. Clinical outcome was assessed after 3 months.

RESULTS: No correlation was found between plasma-NPY and CBF or angiographic vasospasm. The correlation between reduced plasma-NPY and DCI reached borderline statistical significance (P=0.05). Increased levels of NPY measured on days 2 to 4 were correlated to good outcome (P=0.006).

CONCLUSIONS: Our findings in peripheral blood were not supportive of a causal relationship between NPY secretion and DCI. Although high levels of plasma-NPY were correlated with good clinical outcome, NPY did not show promise as a clinically useful biomarker.

OriginalsprogEngelsk
TidsskriftJournal of Neurosurgical Anesthesiology
Sider (fra-til)65-70
Antal sider6
ISSN0898-4921
DOI
StatusUdgivet - 4 maj 2015

ID: 45693004