Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

High long-term test-retest reliability for extrastriatal 11C-raclopride binding in healthy older adults

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Regional times to equilibria and their impact on semi-quantification of [18F]AV-1451 uptake

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cerebral metabolism and vascular reactivity during breath-hold and hypoxic challenge in freedivers and healthy controls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements using 15O-water PET

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Effect of hypoxia on BOLD fMRI response and total cerebral blood flow in migraine with aura patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Improvement in indices of cellular protection after psychological treatment for social anxiety disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Relationships between Physical Activity, Sedentary Behaviour and Cognitive Functions in Office Workers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Development and Feasibility of a Regulated, Supramaximal High-Intensity Training Program Adapted for Older Individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Copenhagen Consensus statement 2019: physical activity and ageing

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Nina Karalija
  • Lars Jonassson
  • Jarkko Johansson
  • Goran Papenberg
  • Alireza Salami
  • Micael Andersson
  • Katrine Riklund
  • Lars Nyberg
  • Carl-Johan Boraxbekk
Vis graf over relationer

In vivo dopamine D2-receptor availability is frequently assessed with 11C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for 11C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal 11C-raclopride binding potential (BPND) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test-retest reliability in a sample of younger adults. The present work demonstrates high seven-month test-retest reliability of striatal and extrastriatal 11C-raclopride BPND values in healthy, older adults (n = 27, age: 64-78 years). Mean 11C-raclopride BPND values were stable between test sessions in subcortical nuclei, and in frontal and temporal cortices (p > 0.05). Across all structures analyzed, intraclass correlation coefficients were high (0.85-0.96), absolute variability was low (mean: 4-8%), and coefficients of variance ranged between 9 and 25%. Furthermore, regional 11C-raclopride BPND values correlated with previously determined 18F-fallypride BPND values (ρ = 0.97 and 0.92 in correlations with and without striatal values, respectively, p < 0.01) and postmortem determined D2-receptor densities (including striatum: ρ = 0.92; p < 0.001; excluding striatum: ρ = 0.75; p = 0.067). These observations suggest that extrastriatal 11C-raclopride measurements represent a true D2 signal.

OriginalsprogEngelsk
TidsskriftJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN0271-678X
DOI
StatusE-pub ahead of print - 10 sep. 2019

ID: 57934270