High long-term test-retest reliability for extrastriatal 11C-raclopride binding in healthy older adults

Nina Karalija, Lars Jonassson, Jarkko Johansson, Goran Papenberg, Alireza Salami, Micael Andersson, Katrine Riklund, Lars Nyberg, Carl-Johan Boraxbekk

15 Citationer (Scopus)


In vivo dopamine D2-receptor availability is frequently assessed with 11C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for 11C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal 11C-raclopride binding potential (BP ND) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test–retest reliability in a sample of younger adults. The present work demonstrates high seven-month test–retest reliability of striatal and extrastriatal 11C-raclopride BP ND values in healthy, older adults (n = 27, age: 64–78 years). Mean 11C-raclopride BP ND values were stable between test sessions in subcortical nuclei, and in frontal and temporal cortices (p > 0.05). Across all structures analyzed, intraclass correlation coefficients were high (0.85–0.96), absolute variability was low (mean: 4–8%), and coefficients of variance ranged between 9 and 25%. Furthermore, regional 11C-raclopride BP ND values correlated with previously determined 18F-fallypride BP ND values (ρ = 0.97 and 0.92 in correlations with and without striatal values, respectively, p < 0.01) and postmortem determined D2-receptor densities (including striatum: ρ = 0.92; p < 0.001; excluding striatum: ρ = 0.75; p = 0.067). These observations suggest that extrastriatal 11C-raclopride measurements represent a true D2 signal.

TidsskriftJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Udgave nummer9
Sider (fra-til)1859-1868
Antal sider10
StatusUdgivet - sep. 2020


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