High frequency of BTG1 deletions in acute lymphoblastic leukemia in children with down syndrome

Catarina Lundin; Lars Hjorth; Mikael Behrendtz; Ann Nordgren; Lars Palmqvist; Mette Klarskov Andersen; Andrea Biloglav; Erik Forestier; Kajsa Maria Paulsson; Bertil Johansson

doi:10.1002/gcc.20944

High frequency of BTG1 deletions in acute lymphoblastic leukemia in children with down syndrome

Catarina Lundin, Lars Hjorth, Mikael Behrendtz, Ann Nordgren, Lars Palmqvist, Mette Klarskov Andersen, Andrea Biloglav, Erik Forestier, Kajsa Maria Paulsson, Bertil Johansson

Afdeling for Genetik

23 Citationer (Scopus)

Abstract

Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with Down syndrome (ML-DS and DS-ALL) have revealed significant differences in abnormality patterns between such cases and acute leukemias in general. Also, certain molecular genetic aberrations characterize DS-related leukemias, such as GATA1 mutations in ML-DS and deregulation of the CRLF2 gene in DS-ALL. Whether microdeletions/microduplications also vary between DS and non-DS cases is presently unclear. To address this issue, we performed single nucleotide polymorphism array analyses of eight pediatric ML-DS and 17 B-cell precursor DS-ALL. In the ML-DS cases, a total of 29 imbalances (20 gains and nine losses) and two partial uniparental isodisomies (pUPDs) were detected. None of the 11 small (defined as

Originalsprog	Engelsk
Tidsskrift	Genes, Chromosomes & Cancer
Vol/bind	51
Udgave nummer	2
Sider (fra-til)	196-206
Antal sider	11
ISSN	1045-2257
DOI	https://doi.org/10.1002/gcc.20944
Status	Udgivet - 2012

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10.1002/gcc.20944

Citationsformater

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title = "High frequency of BTG1 deletions in acute lymphoblastic leukemia in children with down syndrome",

abstract = "Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with Down syndrome (ML-DS and DS-ALL) have revealed significant differences in abnormality patterns between such cases and acute leukemias in general. Also, certain molecular genetic aberrations characterize DS-related leukemias, such as GATA1 mutations in ML-DS and deregulation of the CRLF2 gene in DS-ALL. Whether microdeletions/microduplications also vary between DS and non-DS cases is presently unclear. To address this issue, we performed single nucleotide polymorphism array analyses of eight pediatric ML-DS and 17 B-cell precursor DS-ALL. In the ML-DS cases, a total of 29 imbalances (20 gains and nine losses) and two partial uniparental isodisomies (pUPDs) were detected. None of the 11 small (defined as ",

keywords = "Adolescent, Case-Control Studies, Child, Child, Preschool, Down Syndrome, Female, Gene Deletion, Genetic Association Studies, Humans, Infant, Leukemia, Myeloid, Male, Neoplasm Proteins, Polymorphism, Single Nucleotide, Precursor Cell Lymphoblastic Leukemia-Lymphoma",

author = "Catarina Lundin and Lars Hjorth and Mikael Behrendtz and Ann Nordgren and Lars Palmqvist and Andersen, {Mette Klarskov} and Andrea Biloglav and Erik Forestier and Paulsson, {Kajsa Maria} and Bertil Johansson",

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year = "2012",

doi = "10.1002/gcc.20944",

language = "English",

volume = "51",

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T1 - High frequency of BTG1 deletions in acute lymphoblastic leukemia in children with down syndrome

AU - Lundin, Catarina

AU - Hjorth, Lars

AU - Behrendtz, Mikael

AU - Nordgren, Ann

AU - Palmqvist, Lars

AU - Andersen, Mette Klarskov

AU - Biloglav, Andrea

AU - Forestier, Erik

AU - Paulsson, Kajsa Maria

AU - Johansson, Bertil

PY - 2012

Y1 - 2012

N2 - Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with Down syndrome (ML-DS and DS-ALL) have revealed significant differences in abnormality patterns between such cases and acute leukemias in general. Also, certain molecular genetic aberrations characterize DS-related leukemias, such as GATA1 mutations in ML-DS and deregulation of the CRLF2 gene in DS-ALL. Whether microdeletions/microduplications also vary between DS and non-DS cases is presently unclear. To address this issue, we performed single nucleotide polymorphism array analyses of eight pediatric ML-DS and 17 B-cell precursor DS-ALL. In the ML-DS cases, a total of 29 imbalances (20 gains and nine losses) and two partial uniparental isodisomies (pUPDs) were detected. None of the 11 small (defined as

AB - Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with Down syndrome (ML-DS and DS-ALL) have revealed significant differences in abnormality patterns between such cases and acute leukemias in general. Also, certain molecular genetic aberrations characterize DS-related leukemias, such as GATA1 mutations in ML-DS and deregulation of the CRLF2 gene in DS-ALL. Whether microdeletions/microduplications also vary between DS and non-DS cases is presently unclear. To address this issue, we performed single nucleotide polymorphism array analyses of eight pediatric ML-DS and 17 B-cell precursor DS-ALL. In the ML-DS cases, a total of 29 imbalances (20 gains and nine losses) and two partial uniparental isodisomies (pUPDs) were detected. None of the 11 small (defined as

KW - Adolescent

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Down Syndrome

KW - Female

KW - Gene Deletion

KW - Genetic Association Studies

KW - Humans

KW - Infant

KW - Leukemia, Myeloid

KW - Male

KW - Neoplasm Proteins

KW - Polymorphism, Single Nucleotide

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

U2 - 10.1002/gcc.20944

DO - 10.1002/gcc.20944

M3 - Journal article

C2 - 22072402

SN - 1045-2257

VL - 51

SP - 196

EP - 206

JO - Genes, Chromosomes & Cancer

JF - Genes, Chromosomes & Cancer

IS - 2

ER -

High frequency of BTG1 deletions in acute lymphoblastic leukemia in children with down syndrome

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