High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

Pamela A. Magistrado; Daniel Minja; Justin Doritchamou; Nicaise Tuikue Ndam; Davis John; Christentze Schmiegelow; Achille Massougbodji; Madeleine Dahlbäck; Sisse Bolm Ditlev; Vera V. Pinto; Mafalda Resende; John Lusingu; Thor G. Theander; Ali Salanti; Morten A Nielsen

doi:10.1016/j.vaccine.2010.10.080

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

Pamela A. Magistrado, Daniel Minja, Justin Doritchamou, Nicaise Tuikue Ndam, Davis John, Christentze Schmiegelow, Achille Massougbodji, Madeleine Dahlbäck, Sisse Bolm Ditlev, Vera V. Pinto, Mafalda Resende, John Lusingu, Thor G. Theander, Ali Salanti, Morten A Nielsen

39 Citationer (Scopus)

Abstract

Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.

Originalsprog	Engelsk
Tidsskrift	Vaccine
Vol/bind	29
Udgave nummer	3
Sider (fra-til)	437-43
Antal sider	7
ISSN	0264-410X
DOI	https://doi.org/10.1016/j.vaccine.2010.10.080
Status	Udgivet - 10 jan. 2011

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10.1016/j.vaccine.2010.10.080

Citationsformater

Magistrado, P. A., Minja, D., Doritchamou, J., Ndam, N. T., John, D., Schmiegelow, C., Massougbodji, A., Dahlbäck, M., Ditlev, S. B., Pinto, V. V., Resende, M., Lusingu, J., Theander, T. G., Salanti, A., & Nielsen, M. A. (2011). High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women. Vaccine, 29(3), 437-43. https://doi.org/10.1016/j.vaccine.2010.10.080

Magistrado, PA, Minja, D, Doritchamou, J, Ndam, NT, John, D, Schmiegelow, C, Massougbodji, A, Dahlbäck, M, Ditlev, SB, Pinto, VV, Resende, M, Lusingu, J, Theander, TG , Salanti, A & Nielsen, MA 2011, 'High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women', Vaccine, bind 29, nr. 3, s. 437-43. https://doi.org/10.1016/j.vaccine.2010.10.080

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title = "High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women",

abstract = "Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.",

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author = "Magistrado, {Pamela A.} and Daniel Minja and Justin Doritchamou and Ndam, {Nicaise Tuikue} and Davis John and Christentze Schmiegelow and Achille Massougbodji and Madeleine Dahlb{\"a}ck and Ditlev, {Sisse Bolm} and Pinto, {Vera V.} and Mafalda Resende and John Lusingu and Theander, {Thor G.} and Ali Salanti and Nielsen, {Morten A}",

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doi = "10.1016/j.vaccine.2010.10.080",

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T1 - High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

AU - Magistrado, Pamela A.

AU - Minja, Daniel

AU - Doritchamou, Justin

AU - Ndam, Nicaise Tuikue

AU - John, Davis

AU - Schmiegelow, Christentze

AU - Massougbodji, Achille

AU - Dahlbäck, Madeleine

AU - Ditlev, Sisse Bolm

AU - Pinto, Vera V.

AU - Resende, Mafalda

AU - Lusingu, John

AU - Theander, Thor G.

AU - Salanti, Ali

AU - Nielsen, Morten A

PY - 2011/1/10

Y1 - 2011/1/10

N2 - Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.

AB - Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.

KW - Antibodies, Protozoan

KW - Antigens, Protozoan

KW - Benin

KW - Cell Adhesion

KW - DNA Repair Enzymes

KW - Erythrocytes

KW - Female

KW - Humans

KW - Immunoglobulin G

KW - Malaria Vaccines

KW - Malaria, Falciparum

KW - Plasmodium falciparum

KW - Pregnancy

KW - Pregnancy Complications, Infectious

KW - Recombinant Proteins

KW - Tanzania

KW - Transcription Factors

U2 - 10.1016/j.vaccine.2010.10.080

DO - 10.1016/j.vaccine.2010.10.080

M3 - Journal article

C2 - 21075162

SN - 0264-410X

VL - 29

SP - 437

EP - 443

JO - Vaccine

JF - Vaccine

IS - 3

ER -

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

Abstract

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