Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

High breast milk IL-1β level is associated with reduced risk of childhood eczema

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Bronchoscopic mucosal cryobiopsies as a method for studying airway disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Advancing the management of Obstructive Airways Diseases through Translational Research

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Determinants of low risk of asthma exacerbation during pregnancy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Dynamics of plasma levels of specific IgE in chlorhexidine allergic patients with and without accidental re-exposure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Infant airway microbiota and topical immune perturbations in the origins of childhood asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Environmental and Genetic Determinants of Serum 25(OH)-Vitamin D Levels during Pregnancy and Early Childhood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Neonatal Urine Metabolic Profiling and Development of Childhood Asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: We recently demonstrated a dual effect of breastfeeding with increased risk of eczema and decreased risk of wheezing in early childhood by increasing breastfeeding length. We hypothesize that immune mediators in breast milk could explain such association either through a direct effect or as a surrogate marker of maternal immune constitution.

OBJECTIVE: To investigate the possible association between cytokine and chemokine levels in breast milk and development of eczema and recurrent wheeze during early childhood.

METHODS: Levels of 19 pro-inflammatory and immunoregulatory cytokines and chemokines were measured in 223 breast milk samples from mothers in the Copenhagen Prospective Study on Asthma in Childhood2000 (COPSAC) high-risk birth cohort. Eczema and recurrent wheeze at the age of 0-3 years were prospectively diagnosed by COPSAC physicians adherent to predefined validated algorithms. Association analyses were performed by Cox regression adjusting for potential confounding factors and by multivariable principal component analysis.

RESULTS: Increased IL-1β in breast milk (≥ 0.7 pg/mL) was associated with more than a halved risk of eczema before age three (aHR = 0.41; 95% CI = 0.24-0.68; P < 0.001), which remained significant after false discovery rate adjustment (P = 0.008). The principal component analysis confirmed that a mediator pattern dominated by high levels of IL-1β, IL-17A, and CCL17 and low levels of CXCL1 and TSLP in breast milk protected against eczema (aHR = 0.82; 95% CI = 0.68-0.98; P = 0.03). No associations were observed for recurrent wheeze.

CONCLUSIONS AND CLINICAL RELEVANCE: Elevated breast milk IL-1β level was associated with decreased risk of early childhood eczema suggesting either a direct protective effect of IL-1β or IL-1b acting as a proxy for a healthy maternal immune system protecting high-risk offspring from eczema.

OriginalsprogEngelsk
TidsskriftClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Vol/bind46
Udgave nummer10
Sider (fra-til)1344-1354
ISSN0954-7894
DOI
StatusUdgivet - okt. 2016

ID: 48219152