Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

J Eugen-Olsen, Anton Iversen, P Garred, Uffe Koppelhus, C Pedersen, Thomas Benfield, A M Sorensen, T Katzenstein, E Dickmeiss, J Gerstoft, P Skinhøj, A Svejgaard, J O Nielsen, B Hofmann

204 Citationer (Scopus)

Abstract

Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.
OriginalsprogEngelsk
TidsskriftAIDS
Vol/bind11
Udgave nummer3
Sider (fra-til)305-10
Antal sider6
ISSN0269-9370
StatusUdgivet - 1997

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