Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

J Eugen-Olsen; Anton Iversen; P Garred; Uffe Koppelhus; C Pedersen; Thomas Benfield; A M Sorensen; T Katzenstein; E Dickmeiss; J Gerstoft; P Skinhøj; A Svejgaard; J O Nielsen; B Hofmann

Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

J Eugen-Olsen, Anton Iversen, P Garred, Uffe Koppelhus, C Pedersen, Thomas Benfield, A M Sorensen, T Katzenstein, E Dickmeiss, J Gerstoft, P Skinhøj, A Svejgaard, J O Nielsen, B Hofmann

205 Citationer (Scopus)

Abstract

Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.

Originalsprog	Engelsk
Tidsskrift	AIDS
Vol/bind	11
Udgave nummer	3
Sider (fra-til)	305-10
Antal sider	6
ISSN	0269-9370
Status	Udgivet - 1997

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Eugen-Olsen, J., Iversen, A., Garred, P., Koppelhus, U., Pedersen, C., Benfield, T., Sorensen, A. M., Katzenstein, T., Dickmeiss, E., Gerstoft, J., Skinhøj, P., Svejgaard, A., Nielsen, J. O., & Hofmann, B. (1997). Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS, 11(3), 305-10.

Eugen-Olsen, J, Iversen, A, Garred, P, Koppelhus, U, Pedersen, C, Benfield, T, Sorensen, AM, Katzenstein, T, Dickmeiss, E, Gerstoft, J, Skinhøj, P, Svejgaard, A, Nielsen, JO & Hofmann, B 1997, 'Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals', AIDS, bind 11, nr. 3, s. 305-10.

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title = "Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals",

abstract = "Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.",

keywords = "CD4 Lymphocyte Count, Cohort Studies, Disease-Free Survival, Gene Deletion, HIV Seropositivity, Heterozygote Detection, Humans, Male, Polymerase Chain Reaction, Receptors, CCR5, Receptors, Cytokine, Receptors, HIV",

author = "J Eugen-Olsen and Anton Iversen and P Garred and Uffe Koppelhus and C Pedersen and Thomas Benfield and Sorensen, \{A M\} and T Katzenstein and E Dickmeiss and J Gerstoft and P Skinh{\o}j and A Svejgaard and Nielsen, \{J O\} and B Hofmann",

year = "1997",

language = "English",

volume = "11",

pages = "305--10",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

AU - Eugen-Olsen, J

AU - Iversen, Anton

AU - Garred, P

AU - Koppelhus, Uffe

AU - Pedersen, C

AU - Benfield, Thomas

AU - Sorensen, A M

AU - Katzenstein, T

AU - Dickmeiss, E

AU - Gerstoft, J

AU - Skinhøj, P

AU - Svejgaard, A

AU - Nielsen, J O

AU - Hofmann, B

PY - 1997

Y1 - 1997

N2 - Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.

AB - Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.

KW - CD4 Lymphocyte Count

KW - Cohort Studies

KW - Disease-Free Survival

KW - Gene Deletion

KW - HIV Seropositivity

KW - Heterozygote Detection

KW - Humans

KW - Male

KW - Polymerase Chain Reaction

KW - Receptors, CCR5

KW - Receptors, Cytokine

KW - Receptors, HIV

UR - https://www.scopus.com/pages/publications/8044258978

M3 - Journal article

C2 - 9147421

SN - 0269-9370

VL - 11

SP - 305

EP - 310

JO - AIDS

JF - AIDS

IS - 3

ER -

Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

Abstract

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