Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Heterogeneity of expression of immunohistochemical tumour markers in testicular carcinoma in situ: pathogenetic relevance

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Lymphomas of the head and neck region: an update

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Reduced H3K27me3 expression in radiation-associated angiosarcoma of the breast

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. High maternal age at first and subsequent child births in Denmark in the mid-1800s-Letter to the editor

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Testicular carcinoma in situ (CIS) is the precursor of germ cell tumours in adults, except for spermatocytic seminoma. The mechanism of the progression from premalignant CIS to invasive and overt tumours is largely unknown. There are currently two main hypotheses: one is that CIS can progress directly to either seminoma or nonseminoma; according to the other, seminoma is the intermediate stage between CIS and nonseminoma. CIS cells express several tumour antigens, such as placental-like alkaline phosphatase (PLAP), TRA-1-60, or the c-kit proto-oncogene protein product (Kit), which are present to varying degrees in the invasive germ cell tumours. In this study, CIS cells adjacent to either pure or combined tumours were examined by double immunohistochemical staining for simultaneous expression of TRA-1-60 (typical for embryonal carcinoma) and either Kit (expressed by seminomas) or PLAP (found mainly in seminomas, but also in some cases of nonseminoma). Marked differences in the expression of these antigens were found among CIS cells, especially those adjacent to mixed tumours. We conclude that CIS is a phenotypically heterogeneous lesion, and that the CIS cells, despite identical morphology and close spatial localization, may be in different stages of progression. The results lend support to the hypothesis that CIS can progress directly to both seminomatous and nonseminomatous tumours.

OriginalsprogEngelsk
TidsskriftVirchows Archiv : an international journal of pathology
Vol/bind428
Udgave nummer3
Sider (fra-til)133-9
Antal sider7
ISSN0945-6317
StatusUdgivet - jun. 1996

ID: 44857229