Genetic defects in SLURP1, a "lymphocyte antigen 6" (Ly6)-like protein, cause mal de Meleda, a palmoplantar keratoderma (PPK). The hallmark of Ly6 proteins is an 80-amino acid domain containing 10 cysteines, all arranged in a characteristic spacing pattern and all disulfide-bonded, creating a three-fingered structural motif (Fig. 1). This sequence motif was initially found in cobra and viper toxins, but was later identified in ~25 mammalian proteins. This article is protected by copyright. All rights reserved.
|Tidsskrift||British Journal of Dermatology|
|Status||Udgivet - okt. 2015|