Heterogeneity in the Properties of Mutant SLURP1 Proteins in Mal de Meleda

O Adeyo; M Oberer; M Ploug; L G Fong; S G Young; A P Beigneux

doi:10.1111/bjd.13868

Heterogeneity in the Properties of Mutant SLURP1 Proteins in Mal de Meleda

O Adeyo, M Oberer, M Ploug, L G Fong, S G Young, A P Beigneux

8 Citationer (Scopus)

Abstrakt

Genetic defects in SLURP1, a "lymphocyte antigen 6" (Ly6)-like protein, cause mal de Meleda, a palmoplantar keratoderma (PPK). The hallmark of Ly6 proteins is an 80-amino acid domain containing 10 cysteines, all arranged in a characteristic spacing pattern and all disulfide-bonded, creating a three-fingered structural motif (Fig. 1). This sequence motif was initially found in cobra and viper toxins, but was later identified in ~25 mammalian proteins. This article is protected by copyright. All rights reserved.

Originalsprog	Engelsk
Tidsskrift	British Journal of Dermatology
Vol/bind	173
Udgave nummer	4
Sider (fra-til)	1066-69
ISSN	0007-0963
DOI	https://doi.org/10.1111/bjd.13868
Status	Udgivet - okt. 2015

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10.1111/bjd.13868

Citationsformater

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title = "Heterogeneity in the Properties of Mutant SLURP1 Proteins in Mal de Meleda",

abstract = "Genetic defects in SLURP1, a {"}lymphocyte antigen 6{"} (Ly6)-like protein, cause mal de Meleda, a palmoplantar keratoderma (PPK). The hallmark of Ly6 proteins is an 80-amino acid domain containing 10 cysteines, all arranged in a characteristic spacing pattern and all disulfide-bonded, creating a three-fingered structural motif (Fig. 1). This sequence motif was initially found in cobra and viper toxins, but was later identified in ~25 mammalian proteins. This article is protected by copyright. All rights reserved.",

author = "O Adeyo and M Oberer and M Ploug and Fong, {L G} and Young, {S G} and Beigneux, {A P}",

year = "2015",

month = oct,

doi = "10.1111/bjd.13868",

language = "English",

volume = "173",

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TY - JOUR

T1 - Heterogeneity in the Properties of Mutant SLURP1 Proteins in Mal de Meleda

AU - Adeyo, O

AU - Oberer, M

AU - Ploug, M

AU - Fong, L G

AU - Young, S G

AU - Beigneux, A P

PY - 2015/10

Y1 - 2015/10

N2 - Genetic defects in SLURP1, a "lymphocyte antigen 6" (Ly6)-like protein, cause mal de Meleda, a palmoplantar keratoderma (PPK). The hallmark of Ly6 proteins is an 80-amino acid domain containing 10 cysteines, all arranged in a characteristic spacing pattern and all disulfide-bonded, creating a three-fingered structural motif (Fig. 1). This sequence motif was initially found in cobra and viper toxins, but was later identified in ~25 mammalian proteins. This article is protected by copyright. All rights reserved.

AB - Genetic defects in SLURP1, a "lymphocyte antigen 6" (Ly6)-like protein, cause mal de Meleda, a palmoplantar keratoderma (PPK). The hallmark of Ly6 proteins is an 80-amino acid domain containing 10 cysteines, all arranged in a characteristic spacing pattern and all disulfide-bonded, creating a three-fingered structural motif (Fig. 1). This sequence motif was initially found in cobra and viper toxins, but was later identified in ~25 mammalian proteins. This article is protected by copyright. All rights reserved.

U2 - 10.1111/bjd.13868

DO - 10.1111/bjd.13868

M3 - Journal article

C2 - 25919322

VL - 173

SP - 1066

EP - 1069

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 4

ER -

Heterogeneity in the Properties of Mutant SLURP1 Proteins in Mal de Meleda

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