Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Twin studies have provided evidence that both genetic and environmental factors contribute to schizophrenia (SZ) risk. Heritability estimates of SZ in twin samples have varied methodologically. This study provides updated heritability estimates based on nationwide twin data and an improved statistical methodology.

METHODS: Combining two nationwide registers, the Danish Twin Register and the Danish Psychiatric Research Register, we identified a sample of twins born between 1951 and 2000 (N = 31,524 twin pairs). Twins were followed until June 1, 2011. Liability threshold models adjusting for censoring with inverse probability weighting were used to estimate probandwise concordance rates and heritability of the diagnoses of SZ and SZ spectrum disorders.

RESULTS: The probandwise concordance rate of SZ is 33% in monozygotic twins and 7% in dizygotic twins. We estimated the heritability of SZ to be 79%. When expanding illness outcome to include SZ spectrum disorders, the heritability estimate was almost similar (73%).

CONCLUSIONS: The key strength of this study is the application of a novel statistical method accounting for censoring in the follow-up period to a nationwide twin sample. The estimated 79% heritability of SZ is congruent with previous reports and indicates a substantial genetic risk. The high genetic risk also applies to a broader phenotype of SZ spectrum disorders. The low concordance rate of 33% in monozygotic twins demonstrates that illness vulnerability is not solely indicated by genetic factors.

OriginalsprogEngelsk
Artikelnummer83
TidsskriftBiological Psychiatry
Sider (fra-til)492-498
Antal sider7
ISSN0006-3223
DOI
StatusUdgivet - 9 feb. 2018

ID: 51989880