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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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Vis graf over relationer

Conformational dynamics of viral envelope proteins seem to be involved in mediating evasion from neutralizing antibodies (NAbs) by mechanisms that limit exposure of conserved protein motifs. For hepatitis C virus (HCV), molecular studies have only recently begun to unveil how such dynamics of the envelope protein heterodimer, E1/E2, are linked to viral entry and NAb evasion. Here, we review data suggesting that E1/E2 exists in an equilibrium between theoretical 'open' (NAb-sensitive) and 'closed' (NAb-resistant) conformational states. We describe how this equilibrium is influenced by viral sequence polymorphisms and that it is critically dependent on the N-terminal region of E2, termed hypervariable region 1 (HVR1). Finally, we discuss how it appears that the virus binding site for the HCV entry co-receptor CD81 is less available in 'closed' E1/E2 states and that NAb-resistant viruses require a more intricate entry pathway involving also the entry co-receptor, SR-BI.

OriginalsprogEngelsk
TidsskriftCurrent opinion in virology
Vol/bind50
Sider (fra-til)69-75
Antal sider7
ISSN1879-6257
DOI
StatusUdgivet - okt. 2021

ID: 67246542