TY - JOUR
T1 - Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults
AU - Mocroft, Amanda
AU - Neuhaus, Jacqueline
AU - Peters, Lars
AU - Ryom, Lene
AU - Bickel, Markus
AU - Grint, Daniel
AU - Koirala, Janak
AU - Szymczak, Aleksandra
AU - Lundgren, Jens
AU - Ross, Michael J
AU - Wyatt, Christina M
AU - INSIGHT SMART Study Group
PY - 2012
Y1 - 2012
N2 - Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-positive individuals. Hepatitis C (HCV) co-infection has been associated with increased risk of CKD, but prior studies lack information on potential mechanisms. We evaluated the association between HCV or hepatitis B (HBV) co-infection and progressive CKD among 3,441 antiretroviral-treated clinical trial participants. Progressive CKD was defined as the composite of end-stage renal disease, renal death, or significant glomerular filtration rate (eGFR) decline (25% decline to eGFR 800,000 IU/ml had increased odds (OR 3.07; 95% CI 1.60-5.90). Interleukin-6, hyaluronic acid, and the FIB-4 hepatic fibrosis index were higher among participants who developed progressive CKD, but were no longer associated with progressive CKD after adjustment. Future studies should validate the relationship between HCV viremia and CKD. Trial registration: ClinicalTrials.gov NCT00027352; NCT00004978.
AB - Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-positive individuals. Hepatitis C (HCV) co-infection has been associated with increased risk of CKD, but prior studies lack information on potential mechanisms. We evaluated the association between HCV or hepatitis B (HBV) co-infection and progressive CKD among 3,441 antiretroviral-treated clinical trial participants. Progressive CKD was defined as the composite of end-stage renal disease, renal death, or significant glomerular filtration rate (eGFR) decline (25% decline to eGFR 800,000 IU/ml had increased odds (OR 3.07; 95% CI 1.60-5.90). Interleukin-6, hyaluronic acid, and the FIB-4 hepatic fibrosis index were higher among participants who developed progressive CKD, but were no longer associated with progressive CKD after adjustment. Future studies should validate the relationship between HCV viremia and CKD. Trial registration: ClinicalTrials.gov NCT00027352; NCT00004978.
U2 - 10.1371/journal.pone.0040245
DO - 10.1371/journal.pone.0040245
M3 - Journal article
C2 - 22911697
SN - 1932-6203
VL - 7
SP - e40245
JO - P L o S One
JF - P L o S One
IS - 7
ER -