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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Hepatic effects of dietary weight loss in morbidly obese subjects

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  • T Andersen
  • C Gluud
  • Magnus Franzmann
  • Pernille Yde Christoffersen
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This prospective study was carried out in order to evaluate the influence on liver morphology and function of a very-low-calorie formula diet. Fourty-one morbidly obese, non-alcoholic subjects had liver biopsy performed before and after a median weight loss of 34 kg. Fatty change improved (p less than 0.001), but 24% of the patients developed slight portal inflammation (p = 0.039) or slight portal fibrosis (p = 0.063). Patients developing portal fibrosis had a higher degree of fatty change at entry (p = 0.029), a more pronounced reduction of fatty change (p = 0.014) and a faster weight loss (p = 0.026). Liver biochemistry, which was of no individual diagnostic value, improved. It is concluded that morbidly obese subjects with a high degree of hepatic fatty change are at risk of developing portal inflammation and fibrosis when undergoing very fast dietary weight reductions.
OriginalsprogEngelsk
TidsskriftJournal of Hepatology
Vol/bind12
Udgave nummer2
Sider (fra-til)224-9
Antal sider6
ISSN0168-8278
StatusUdgivet - mar. 1991

ID: 38932010