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HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. BloodSpot: a database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Identification of two distinct pathways of human myelopoiesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
The HemaExplorer (http://servers.binf.ku.dk/hemaexplorer) is a curated database of processed mRNA Gene expression profiles (GEPs) that provides an easy display of gene expression in haematopoietic cells. HemaExplorer contains GEPs derived from mouse/human haematopoietic stem and progenitor cells as well as from more differentiated cell types. Moreover, data from distinct subtypes of human acute myeloid leukemia is included in the database allowing researchers to directly compare gene expression of leukemic cells with those of their closest normal counterpart. Normalization and batch correction lead to full integrity of the data in the database. The HemaExplorer has comprehensive visualization interface that can make it useful as a daily tool for biologists and cancer researchers to assess the expression patterns of genes encountered in research or literature. HemaExplorer is relevant for all research within the fields of leukemia, immunology, cell differentiation and the biology of the haematopoietic system.
OriginalsprogEngelsk
TidsskriftNucleic Acids Research
Vol/bind41
Udgave nummerDatabase issue
Sider (fra-til)D1034-9
ISSN0305-1048
DOI
StatusUdgivet - 2013

ID: 36840252