Heart rate variability in bipolar disorder: A systematic review and meta-analysis

Maria Faurholt-Jepsen; Lars Vedel Kessing; Klaus Munkholm

doi:10.1016/j.neubiorev.2016.12.007

Heart rate variability in bipolar disorder: A systematic review and meta-analysis

Maria Faurholt-Jepsen, Lars Vedel Kessing, Klaus Munkholm

101 Citationer (Scopus)

Abstract

BACKGROUND: Heart rate variability (HRV) has been suggested reduced in bipolar disorder (BD) compared with healthy individuals (HC). This meta-analysis investigated: HRV differences in BD compared with HC, major depressive disorder or schizophrenia; HRV differences between affective states; HRV changes from mania/depression to euthymia; and HRV changes following interventions.

METHODS: A systematic review and meta-analysis reported according to the PRISMA guidelines was conducted. MEDLINE, Embase, PsycINFO, The Cochrane Library and Scopus were searched. A total of 15 articles comprising 2534 individuals were included.

RESULTS: HRV was reduced in BD compared to HC (g=-1.77, 95% CI: -2.46; -1.09, P<0.001, 10 comparisons, n=1581). More recent publication year, larger study and higher study quality were associated with a smaller difference in HRV. Large between-study heterogeneity, low study quality, and lack of consideration of confounding factors in individual studies were observed.

CONCLUSIONS: This first meta-analysis of HRV in BD suggests that HRV is reduced in BD compared to HC. Heterogeneity and methodological issues limit the evidence. Future studies employing strict methodology are warranted.

Originalsprog	Engelsk
Tidsskrift	Neuroscience & Biobehavioral Reviews
Vol/bind	73
Sider (fra-til)	68-80
Antal sider	13
ISSN	0149-7634
DOI	https://doi.org/10.1016/j.neubiorev.2016.12.007
Status	Udgivet - 13 dec. 2016

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10.1016/j.neubiorev.2016.12.007

Citationsformater

@article{50947e85697644c2acf2d6650fd48a3d,

title = "Heart rate variability in bipolar disorder: A systematic review and meta-analysis",

abstract = "BACKGROUND: Heart rate variability (HRV) has been suggested reduced in bipolar disorder (BD) compared with healthy individuals (HC). This meta-analysis investigated: HRV differences in BD compared with HC, major depressive disorder or schizophrenia; HRV differences between affective states; HRV changes from mania/depression to euthymia; and HRV changes following interventions.METHODS: A systematic review and meta-analysis reported according to the PRISMA guidelines was conducted. MEDLINE, Embase, PsycINFO, The Cochrane Library and Scopus were searched. A total of 15 articles comprising 2534 individuals were included.RESULTS: HRV was reduced in BD compared to HC (g=-1.77, 95% CI: -2.46; -1.09, P<0.001, 10 comparisons, n=1581). More recent publication year, larger study and higher study quality were associated with a smaller difference in HRV. Large between-study heterogeneity, low study quality, and lack of consideration of confounding factors in individual studies were observed.CONCLUSIONS: This first meta-analysis of HRV in BD suggests that HRV is reduced in BD compared to HC. Heterogeneity and methodological issues limit the evidence. Future studies employing strict methodology are warranted.",

author = "Maria Faurholt-Jepsen and Kessing, {Lars Vedel} and Klaus Munkholm",

year = "2016",

month = dec,

day = "13",

doi = "10.1016/j.neubiorev.2016.12.007",

language = "English",

volume = "73",

pages = "68--80",

journal = "Neuroscience & Biobehavioral Reviews",

issn = "0149-7634",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Heart rate variability in bipolar disorder

T2 - A systematic review and meta-analysis

AU - Faurholt-Jepsen, Maria

AU - Kessing, Lars Vedel

AU - Munkholm, Klaus

PY - 2016/12/13

Y1 - 2016/12/13

N2 - BACKGROUND: Heart rate variability (HRV) has been suggested reduced in bipolar disorder (BD) compared with healthy individuals (HC). This meta-analysis investigated: HRV differences in BD compared with HC, major depressive disorder or schizophrenia; HRV differences between affective states; HRV changes from mania/depression to euthymia; and HRV changes following interventions.METHODS: A systematic review and meta-analysis reported according to the PRISMA guidelines was conducted. MEDLINE, Embase, PsycINFO, The Cochrane Library and Scopus were searched. A total of 15 articles comprising 2534 individuals were included.RESULTS: HRV was reduced in BD compared to HC (g=-1.77, 95% CI: -2.46; -1.09, P<0.001, 10 comparisons, n=1581). More recent publication year, larger study and higher study quality were associated with a smaller difference in HRV. Large between-study heterogeneity, low study quality, and lack of consideration of confounding factors in individual studies were observed.CONCLUSIONS: This first meta-analysis of HRV in BD suggests that HRV is reduced in BD compared to HC. Heterogeneity and methodological issues limit the evidence. Future studies employing strict methodology are warranted.

AB - BACKGROUND: Heart rate variability (HRV) has been suggested reduced in bipolar disorder (BD) compared with healthy individuals (HC). This meta-analysis investigated: HRV differences in BD compared with HC, major depressive disorder or schizophrenia; HRV differences between affective states; HRV changes from mania/depression to euthymia; and HRV changes following interventions.METHODS: A systematic review and meta-analysis reported according to the PRISMA guidelines was conducted. MEDLINE, Embase, PsycINFO, The Cochrane Library and Scopus were searched. A total of 15 articles comprising 2534 individuals were included.RESULTS: HRV was reduced in BD compared to HC (g=-1.77, 95% CI: -2.46; -1.09, P<0.001, 10 comparisons, n=1581). More recent publication year, larger study and higher study quality were associated with a smaller difference in HRV. Large between-study heterogeneity, low study quality, and lack of consideration of confounding factors in individual studies were observed.CONCLUSIONS: This first meta-analysis of HRV in BD suggests that HRV is reduced in BD compared to HC. Heterogeneity and methodological issues limit the evidence. Future studies employing strict methodology are warranted.

U2 - 10.1016/j.neubiorev.2016.12.007

DO - 10.1016/j.neubiorev.2016.12.007

M3 - Journal article

C2 - 27986468

SN - 0149-7634

VL - 73

SP - 68

EP - 80

JO - Neuroscience & Biobehavioral Reviews

JF - Neuroscience & Biobehavioral Reviews

ER -

Heart rate variability in bipolar disorder: A systematic review and meta-analysis

Abstract

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