Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy

Nille B Wulff; Susanne O Dalton; Irene Wessel; Beatriz Arenaz Búa; Helena Löfhede; Eva Hammerlid; Trille K Kjaer; Christian Godballe; Thomas Kjaergaard; Preben Homøe

doi:10.1002/lary.29857

Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy

Nille B Wulff, Susanne O Dalton, Irene Wessel, Beatriz Arenaz Búa, Helena Löfhede, Eva Hammerlid, Trille K Kjaer, Christian Godballe, Thomas Kjaergaard, Preben Homøe

Afdeling for Øre-Næse-Halskirurgi og Audiologi

33 Citationer (Scopus)

Abstract

OBJECTIVES/HYPOTHESIS: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects.

STUDY DESIGN: Cross-sectional study.

METHODS: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires.

RESULTS: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score.

CONCLUSION: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL.

LEVEL OF EVIDENCE: 3 Laryngoscope, 132:980-988, 2022.

Originalsprog	Engelsk
Tidsskrift	The Laryngoscope
Vol/bind	132
Udgave nummer	5
Sider (fra-til)	980-988
Antal sider	9
ISSN	0023-852X
DOI	https://doi.org/10.1002/lary.29857
Status	Udgivet - maj 2022

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10.1002/lary.29857

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title = "Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy",

abstract = "OBJECTIVES/HYPOTHESIS: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects.STUDY DESIGN: Cross-sectional study.METHODS: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires.RESULTS: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score.CONCLUSION: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL.LEVEL OF EVIDENCE: 3 Laryngoscope, 132:980-988, 2022.",

keywords = "depression, dysphagia, health-related quality of life, Total laryngectomy, voice problems",

author = "Wulff, {Nille B} and Dalton, {Susanne O} and Irene Wessel and {Arenaz B{\'u}a}, Beatriz and Helena L{\"o}fhede and Eva Hammerlid and Kjaer, {Trille K} and Christian Godballe and Thomas Kjaergaard and Preben Hom{\o}e",

note = "{\textcopyright} 2021 The American Laryngological, Rhinological and Otological Society, Inc.",

year = "2022",

month = may,

doi = "10.1002/lary.29857",

language = "English",

volume = "132",

pages = "980--988",

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TY - JOUR

T1 - Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy

AU - Wulff, Nille B

AU - Dalton, Susanne O

AU - Wessel, Irene

AU - Arenaz Búa, Beatriz

AU - Löfhede, Helena

AU - Hammerlid, Eva

AU - Kjaer, Trille K

AU - Godballe, Christian

AU - Kjaergaard, Thomas

AU - Homøe, Preben

PY - 2022/5

Y1 - 2022/5

N2 - OBJECTIVES/HYPOTHESIS: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects.STUDY DESIGN: Cross-sectional study.METHODS: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires.RESULTS: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score.CONCLUSION: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL.LEVEL OF EVIDENCE: 3 Laryngoscope, 132:980-988, 2022.

AB - OBJECTIVES/HYPOTHESIS: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects.STUDY DESIGN: Cross-sectional study.METHODS: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires.RESULTS: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score.CONCLUSION: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL.LEVEL OF EVIDENCE: 3 Laryngoscope, 132:980-988, 2022.

KW - depression

KW - dysphagia

KW - health-related quality of life

KW - Total laryngectomy

KW - voice problems

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U2 - 10.1002/lary.29857

DO - 10.1002/lary.29857

M3 - Journal article

C2 - 34490903

SN - 0023-852X

VL - 132

SP - 980

EP - 988

JO - The Laryngoscope

JF - The Laryngoscope

IS - 5

ER -

Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy

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