Has reporting of methods in animal studies in psychiatric research improved since the introduction of the ARRIVE guidelines?

Pia Brandt Danborg, Anders L Simonsen, Asbjørn Hrobjartsson, Peter C. Gøtzsche


    Objective: Animal research has been dominated by poor methodology or poor reporting. The ARRIVE guidelines
    were introduced in 2010 to increase the quality of reporting in animal research. An evaluation by Baker et al (2014)
    reported inadequate adherence to the ARRIVE guidelines by researchers and journal editors. We are undertaking
    two systematic reviews to investigate harms from exposure to psychiatric drugs; one on long-term behavioral harms
    from previous exposure to psychiatric drugs after a drug-free period and one on abnormal development of
    reproductive organs from exposure to ADHD medication.
    Method: Two independent observers assessed risk of bias due to randomization and blinding in studies included in
    either of the two systematic reviews and published in 2011 or later. We used the ARRIVE guidelines for reporting
    and the risk of bias tool presented by the Systematic Review Centre for Animal Experimentation (Netherlands) for
    Results: Sixteen of 58 studies included in the two systematic reviews were published in 2011 or later. Of these, two
    studies reported to have randomized the animals to either intervention or control groups, no studies used random
    housing to prevent influence on behavior from temperature and light differences, and one study used random
    outcome assessment to prevent bias from diurnal variation. No caregivers were adequately described as being
    blinded, and two studies described observers to be blinded.
    Overall, the adherence to the ARRIVE guidelines was poor. The results showed us that animal psychiatric research
    is as methodologically poor or poorly reported as studies published before introduction of the ARRIVE guidelines.
    Conclusion: The implications from poor methodology in research or poor reporting are substantial: resources and
    animals could be allocated to more useful purposes, and important knowledge about harms from psychiatric drugs is
    delayed or hampered. We strongly endorse the use of the ARRIVE reporting guidelines in animal psychiatric
    research. The ARRIVE guidelines should be introduced to researchers early in their education to carry out
    responsible methodological study design. Funding bodies, ethics committees, regulatory agencies and journal
    editors should demand adherence. Actions to improve guideline implementation and adherence at all institutions
    implicated in animal research are clearly necessary.
    Antal sider1
    StatusUdgivet - 2017
    Begivenhed5th World Conference on Research Integrity - Amsterdam, Holland
    Varighed: 28 maj 201731 maj 2017


    Konference5th World Conference on Research Integrity


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