Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Habitual sleep disturbances and migraine: a Mendelian randomization study

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  1. Candy's foundation initiativ on Cephalalgia

    Projekt: Typer af projekterProjekt

  1. High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010-2020

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Artificial intelligence extension of the OSCAR-IB criteria

    Publikation: Bidrag til tidsskriftReviewpeer review

  3. Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. Intravenous arylsulfatase A in metachromatic leukodystrophy: a phase 1/2 study

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  1. The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. The sequences of 150,119 genomes in the UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. Headache provocation by nitric oxide in men who have never experienced a headache

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

OBJECTIVE: Sleep disturbances are associated with increased risk of migraine, however the extent of shared underlying biology and the direction of causal relationships between these traits is unclear. Delineating causality between sleep patterns and migraine may offer new pathophysiologic insights and inform subsequent intervention studies. Here, we used genetic approaches to test for shared genetic influences between sleep patterns and migraine, and to test whether habitual sleep patterns may be causal risk factors for migraine and vice versa.

METHODS: To quantify genetic overlap, we performed genome-wide genetic correlation analyses using genome-wide association studies of nine sleep traits in the UK Biobank (n ≥ 237,627), and migraine from the International Headache Genetics Consortium (59,674 cases and 316,078 controls). We then tested for potential causal effects between sleep traits and migraine using bidirectional, two-sample Mendelian randomization.

RESULTS: Seven sleep traits demonstrated genetic overlap with migraine, including insomnia symptoms (rg = 0.29, P < 10-31 ) and difficulty awakening (rg = 0.11, P < 10-4 ). Mendelian randomization analyses provided evidence for potential causal effects of difficulty awakening on risk of migraine (OR [95% CI] = 1.37 [1.12-1.68], P = 0.002), and nominal evidence that liability to insomnia symptoms increased the risk of migraine (1.09 [1.02-1.16], P = 0.02). In contrast, there was minimal evidence for an effect of migraine liability on sleep patterns or disturbances.

INTERPRETATION: These data support a shared genetic basis between several sleep traits and migraine, and support potential causal effects of difficulty awakening and insomnia symptoms on migraine risk. Treatment of sleep disturbances may therefore be a promising clinical intervention in the management of migraine.

OriginalsprogEngelsk
TidsskriftAnnals of Clinical and Translational Neurology
Vol/bind7
Udgave nummer12
Sider (fra-til)2370-2380
Antal sider11
ISSN2328-9503
DOI
StatusUdgivet - okt. 2020

Bibliografisk note

© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

ID: 61782096