Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Gut hormone release after gastric bypass depends on the length of the biliopancreatic limb

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Do genetic risk scores for childhood adiposity operate independent of BMI of their mothers?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Changes in relationship status following bariatric surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Thyroid function in COVID-19 and the association with cytokine levels and mortality

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Comparison of 16 Serological SARS-CoV-2 Immunoassays in 16 Clinical Laboratories

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Chromogranin A in cardiovascular endocrinology

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  5. Quantification of biotin in plasma samples by column switching liquid chromatography - tandem mass spectrometry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Bárbara G Patrício
  • Tiago Morais
  • Marta Guimarães
  • Simon Veedfald
  • Bolette Hartmann
  • Linda Hilsted
  • Jens J Holst
  • Mário Nora
  • Mariana P Monteiro
Vis graf over relationer

Background/Objectives: Changes in gut hormone secretion are important for the anti-diabetic effects of bariatric surgery. Roux-en-Y gastric bypass (RYGB) with extended biliopancreatic limb (BPL) length may improve the metabolic outcomes when compared to the classical procedure. The purpose of this study was to compare the gut hormone responses to a liquid mixed meal after RYGB with one of two different BPL lengths. Subjects/Methods: Non-diabetic weight-stable individuals previously submitted to classical RYGB (n = 9; BPL length: 87.8 ± 20.5 cm) or long BPL RYGB (n = 11; BPL length: 200 cm) underwent a liquid mixed-meal tolerance test (MMTT). Blood was sampled at baseline and 15, 30, 45, 60, 90 and 120 min later for measurement of plasma glucose, enteropancreatic hormones and total bile acids (TBA). Results: Plasma glucose excursion curves were similar in the two groups. The long BPL RYGB group displayed significantly higher fasting and post-prandial GLP-1 (t = 0 min, p = 0.01 and t = 45 min, p < 0.05; tAUC: 11,205 ± 3399 vs 7889 ± 1686 pmol/L × min, p = 0.02) and neurotensin (t = 0 min, p = 0.02; t = 45 min, p < 0.05 and t = 60 min, p < 0.01; tAUC: 18,392 ± 7066 vs 11,437 ± 3658 pmol/L × min, p = 0.02) levels, while responses of GIP (t = 15 min, p < 0.01), insulin and C-peptide (t = 30 min, p < 0.001) were lower as compared to classical RYGB. There were no differences in glucagon, PP, PYY and TBA between the groups. Conclusions: RYGB with a longer BPL results in a distinctive post-prandial hormone profile with augmented GLP-1 and neurotensin responses that could be beneficial for the metabolic outcomes of the surgery.

OriginalsprogEngelsk
TidsskriftInternational journal of obesity (2005)
Vol/bind43
Udgave nummer5
Sider (fra-til)1009-1018
Antal sider10
ISSN0307-0565
DOI
StatusUdgivet - 1 maj 2019

ID: 58248789