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Gut colonization in preterm infants supplemented with bovine colostrum in the first week of life: An explorative pilot study

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@article{aa7cee63bc0a4f1a8ac1603a667f60e0,
title = "Gut colonization in preterm infants supplemented with bovine colostrum in the first week of life: An explorative pilot study",
abstract = "Background: In the first weeks after birth, enteral feeding and bacterial colonization interact to influence gut maturation in preterm infants. Bovine colostrum (BC) has been suggested as a relevant supplementary diet when own mother's milk (MM) is insufficient or absent. This pilot trial tests whether the supplement type, BC or donor human milk (DM), affects gut colonization in preterm infants during the first week of life. Methods: On day 7, fecal samples were collected from preterm infants (n = 24) fed BC or DM as a supplement to MM. The gut microbiome (GM) was analyzed by 16S ribosomal RNA amplicon sequencing. Correlations between the relative abundance of specific bacterial taxa and blood chemistry variables, including amino acids, were explored. Results: BC-supplemented infants showed a lower relative abundance of the families Lactobacillaceae and Enterococcaceae than DM infants. Planococcaceae were more abundant in infants delivered by cesarean birth vs vaginally. The relative abundance of bacterial families, specifically Enterobacteriaceae, correlated negatively with plasma levels of multiple essential and nonessential amino acids (valine, isoleucine, lysine, histidine, and arginine). Conclusion: The nature of nutrition supplements (BC or DM) just after birth may affect GM development and nutrient metabolism in the neonatal period of preterm infants. The exploratory nature of our study calls for confirmation of these results and their possible long-term clinical implications for preterm infants.",
keywords = "bovine colostrum, fecal microbiome, feeding type, preterm infants",
author = "Jiang, {Ping Ping} and Tik Muk and Lukasz Krych and Nielsen, {Dennis Sandris} and Bekzod Khakimov and Yanqi Li and Juhl, {Sandra Meinich} and Gorm Greisen and Sangild, {Per Torp}",
note = "Funding Information: This work is financially supported by the Innovation Fund Denmark under the Project NEOMUNE (Grant 12–132401 to Per Torp Sangild). Ping‐Ping Jiang received support from the Sun Yat‐sen University (2017181). Publisher Copyright: {\textcopyright} 2021 American Society for Parenteral and Enteral Nutrition Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
doi = "10.1002/jpen.2191",
language = "English",
journal = "Journal of Parenteral and Enteral Nutrition",
issn = "0148-6071",
publisher = "Sage Science Press (US)",

}

RIS

TY - JOUR

T1 - Gut colonization in preterm infants supplemented with bovine colostrum in the first week of life

T2 - An explorative pilot study

AU - Jiang, Ping Ping

AU - Muk, Tik

AU - Krych, Lukasz

AU - Nielsen, Dennis Sandris

AU - Khakimov, Bekzod

AU - Li, Yanqi

AU - Juhl, Sandra Meinich

AU - Greisen, Gorm

AU - Sangild, Per Torp

N1 - Funding Information: This work is financially supported by the Innovation Fund Denmark under the Project NEOMUNE (Grant 12–132401 to Per Torp Sangild). Ping‐Ping Jiang received support from the Sun Yat‐sen University (2017181). Publisher Copyright: © 2021 American Society for Parenteral and Enteral Nutrition Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - Background: In the first weeks after birth, enteral feeding and bacterial colonization interact to influence gut maturation in preterm infants. Bovine colostrum (BC) has been suggested as a relevant supplementary diet when own mother's milk (MM) is insufficient or absent. This pilot trial tests whether the supplement type, BC or donor human milk (DM), affects gut colonization in preterm infants during the first week of life. Methods: On day 7, fecal samples were collected from preterm infants (n = 24) fed BC or DM as a supplement to MM. The gut microbiome (GM) was analyzed by 16S ribosomal RNA amplicon sequencing. Correlations between the relative abundance of specific bacterial taxa and blood chemistry variables, including amino acids, were explored. Results: BC-supplemented infants showed a lower relative abundance of the families Lactobacillaceae and Enterococcaceae than DM infants. Planococcaceae were more abundant in infants delivered by cesarean birth vs vaginally. The relative abundance of bacterial families, specifically Enterobacteriaceae, correlated negatively with plasma levels of multiple essential and nonessential amino acids (valine, isoleucine, lysine, histidine, and arginine). Conclusion: The nature of nutrition supplements (BC or DM) just after birth may affect GM development and nutrient metabolism in the neonatal period of preterm infants. The exploratory nature of our study calls for confirmation of these results and their possible long-term clinical implications for preterm infants.

AB - Background: In the first weeks after birth, enteral feeding and bacterial colonization interact to influence gut maturation in preterm infants. Bovine colostrum (BC) has been suggested as a relevant supplementary diet when own mother's milk (MM) is insufficient or absent. This pilot trial tests whether the supplement type, BC or donor human milk (DM), affects gut colonization in preterm infants during the first week of life. Methods: On day 7, fecal samples were collected from preterm infants (n = 24) fed BC or DM as a supplement to MM. The gut microbiome (GM) was analyzed by 16S ribosomal RNA amplicon sequencing. Correlations between the relative abundance of specific bacterial taxa and blood chemistry variables, including amino acids, were explored. Results: BC-supplemented infants showed a lower relative abundance of the families Lactobacillaceae and Enterococcaceae than DM infants. Planococcaceae were more abundant in infants delivered by cesarean birth vs vaginally. The relative abundance of bacterial families, specifically Enterobacteriaceae, correlated negatively with plasma levels of multiple essential and nonessential amino acids (valine, isoleucine, lysine, histidine, and arginine). Conclusion: The nature of nutrition supplements (BC or DM) just after birth may affect GM development and nutrient metabolism in the neonatal period of preterm infants. The exploratory nature of our study calls for confirmation of these results and their possible long-term clinical implications for preterm infants.

KW - bovine colostrum

KW - fecal microbiome

KW - feeding type

KW - preterm infants

UR - http://www.scopus.com/inward/record.url?scp=85108279223&partnerID=8YFLogxK

U2 - 10.1002/jpen.2191

DO - 10.1002/jpen.2191

M3 - Journal article

C2 - 33988859

AN - SCOPUS:85108279223

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

SN - 0148-6071

ER -

ID: 67283313