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Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study

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Harvard

Nordal, E, Pistorio, A, Rygg, M, Giancane, G, Maghnie, M, Di Iorgi, N, Flemming, K, Hofer, M, Melo-Gomes, JA, Bica, BERG, Brunner, J, Dannecker, G, Gerloni, V, Harjacek, M, Huppertz, H-I, Pratsidou-Gertsi, P, Nielsen, S, Stanevicha, V, Ten Cate, R, Vougiouka, O, Pastore, S, Simonini, G, Ravelli, A, Martini, A, Ruperto, N & Paediatric Rheumatology International Trials Organisation (PRINTO) 2020, 'Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study' Arthritis Care & Research, bind 72, nr. 2, s. 265-273. https://doi.org/10.1002/acr.24065

APA

Nordal, E., Pistorio, A., Rygg, M., Giancane, G., Maghnie, M., Di Iorgi, N., ... Paediatric Rheumatology International Trials Organisation (PRINTO) (2020). Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study. Arthritis Care & Research, 72(2), 265-273. https://doi.org/10.1002/acr.24065

CBE

Nordal E, Pistorio A, Rygg M, Giancane G, Maghnie M, Di Iorgi N, Flemming K, Hofer M, Melo-Gomes JA, Bica BERG, Brunner J, Dannecker G, Gerloni V, Harjacek M, Huppertz H-I, Pratsidou-Gertsi P, Nielsen S, Stanevicha V, Ten Cate R, Vougiouka O, Pastore S, Simonini G, Ravelli A, Martini A, Ruperto N, Paediatric Rheumatology International Trials Organisation (PRINTO). 2020. Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study. Arthritis Care & Research. 72(2):265-273. https://doi.org/10.1002/acr.24065

MLA

Vancouver

Nordal E, Pistorio A, Rygg M, Giancane G, Maghnie M, Di Iorgi N o.a. Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study. Arthritis Care & Research. 2020 feb;72(2):265-273. https://doi.org/10.1002/acr.24065

Author

Nordal, Ellen ; Pistorio, Angela ; Rygg, Marite ; Giancane, Gabriella ; Maghnie, Mohamad ; Di Iorgi, Natascia ; Flemming, Kristina ; Hofer, Michael ; Melo-Gomes, Jose A ; Bica, Blanca E R G ; Brunner, Jurgen ; Dannecker, Günther ; Gerloni, Valeria ; Harjacek, Miroslav ; Huppertz, Hans-Iko ; Pratsidou-Gertsi, Polyxeni ; Nielsen, Susan ; Stanevicha, Valda ; Ten Cate, Rebecca ; Vougiouka, Olga ; Pastore, Serena ; Simonini, Gabriele ; Ravelli, Angelo ; Martini, Alberto ; Ruperto, Nicolino ; Paediatric Rheumatology International Trials Organisation (PRINTO). / Growth and puberty in juvenile dermatomyositis : a longitudinal cohort study. I: Arthritis Care & Research. 2020 ; Bind 72, Nr. 2. s. 265-273.

Bibtex

@article{08a0ab6d6e7e4b4ebf20d6b084e89528,
title = "Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study",
abstract = "OBJECTIVE: To study growth and puberty in a multinational longitudinal prospective cohort of children with juvenile dermatomyositis (DM).METHODS: Children from 31 countries who were ages <18 years and had juvenile DM in active phase were studied, and analyses of height, weight, and pubertal development were conducted in those who had follow-up visits during a 2-year period and for whom anthropometric data was available.RESULTS: A total of 196 of 275 children (71{\%}) were included. We found a significant reduction in parent-adjusted height Z score over time in female patients (P < 0.0001) and male patients (P = 0.001), but with catch-up growth at the final study visit. Median body mass index Z score peaked at 6 months (P < 0.0001) and was still significantly above baseline at the final study visit, which was at a median of 26 months after baseline (P = 0.007), with no difference between sexes. Female patients with a disease duration ≥12 months after onset had significantly lower parent-adjusted height Z score (P = 0.002) and no 2-year catch-up growth. At the final study visit, growth failure was seen in 20 of 97 female patients (21{\%}) and in 11 of 73 male patients (15{\%}). Height deflection (∆height Z score less than -0.25/year) was observed in 29 of 116 female patients (25{\%}) and 25 of 80 male patients (31.3{\%}). Delayed puberty was seen in 20 of 55 female patients (36.4{\%}) and in 11 of 31 male patients (35.5{\%}). Children in early pubertal stage at baseline had the highest risk of growth failure.CONCLUSION: Juvenile DM in the active phase and/or its treatment has a significant impact on growth and puberty in affected children. Children with recent onset of puberty or previous growth failure have the highest risk of delayed pubertal development and further growth retardation.",
keywords = "Adolescent, Child, Child, Preschool, Cohort Studies, Dermatomyositis/diagnosis, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Puberty/physiology",
author = "Ellen Nordal and Angela Pistorio and Marite Rygg and Gabriella Giancane and Mohamad Maghnie and {Di Iorgi}, Natascia and Kristina Flemming and Michael Hofer and Melo-Gomes, {Jose A} and Bica, {Blanca E R G} and Jurgen Brunner and G{\"u}nther Dannecker and Valeria Gerloni and Miroslav Harjacek and Hans-Iko Huppertz and Polyxeni Pratsidou-Gertsi and Susan Nielsen and Valda Stanevicha and {Ten Cate}, Rebecca and Olga Vougiouka and Serena Pastore and Gabriele Simonini and Angelo Ravelli and Alberto Martini and Nicolino Ruperto and {Paediatric Rheumatology International Trials Organisation (PRINTO)}",
note = "{\circledC} 2019, American College of Rheumatology.",
year = "2020",
month = "2",
doi = "10.1002/acr.24065",
language = "English",
volume = "72",
pages = "265--273",
journal = "Arthritis Care & Research",
issn = "2151-464X",
publisher = "JohnWiley & Sons, Inc",
number = "2",

}

RIS

TY - JOUR

T1 - Growth and puberty in juvenile dermatomyositis

T2 - a longitudinal cohort study

AU - Nordal, Ellen

AU - Pistorio, Angela

AU - Rygg, Marite

AU - Giancane, Gabriella

AU - Maghnie, Mohamad

AU - Di Iorgi, Natascia

AU - Flemming, Kristina

AU - Hofer, Michael

AU - Melo-Gomes, Jose A

AU - Bica, Blanca E R G

AU - Brunner, Jurgen

AU - Dannecker, Günther

AU - Gerloni, Valeria

AU - Harjacek, Miroslav

AU - Huppertz, Hans-Iko

AU - Pratsidou-Gertsi, Polyxeni

AU - Nielsen, Susan

AU - Stanevicha, Valda

AU - Ten Cate, Rebecca

AU - Vougiouka, Olga

AU - Pastore, Serena

AU - Simonini, Gabriele

AU - Ravelli, Angelo

AU - Martini, Alberto

AU - Ruperto, Nicolino

AU - Paediatric Rheumatology International Trials Organisation (PRINTO)

N1 - © 2019, American College of Rheumatology.

PY - 2020/2

Y1 - 2020/2

N2 - OBJECTIVE: To study growth and puberty in a multinational longitudinal prospective cohort of children with juvenile dermatomyositis (DM).METHODS: Children from 31 countries who were ages <18 years and had juvenile DM in active phase were studied, and analyses of height, weight, and pubertal development were conducted in those who had follow-up visits during a 2-year period and for whom anthropometric data was available.RESULTS: A total of 196 of 275 children (71%) were included. We found a significant reduction in parent-adjusted height Z score over time in female patients (P < 0.0001) and male patients (P = 0.001), but with catch-up growth at the final study visit. Median body mass index Z score peaked at 6 months (P < 0.0001) and was still significantly above baseline at the final study visit, which was at a median of 26 months after baseline (P = 0.007), with no difference between sexes. Female patients with a disease duration ≥12 months after onset had significantly lower parent-adjusted height Z score (P = 0.002) and no 2-year catch-up growth. At the final study visit, growth failure was seen in 20 of 97 female patients (21%) and in 11 of 73 male patients (15%). Height deflection (∆height Z score less than -0.25/year) was observed in 29 of 116 female patients (25%) and 25 of 80 male patients (31.3%). Delayed puberty was seen in 20 of 55 female patients (36.4%) and in 11 of 31 male patients (35.5%). Children in early pubertal stage at baseline had the highest risk of growth failure.CONCLUSION: Juvenile DM in the active phase and/or its treatment has a significant impact on growth and puberty in affected children. Children with recent onset of puberty or previous growth failure have the highest risk of delayed pubertal development and further growth retardation.

AB - OBJECTIVE: To study growth and puberty in a multinational longitudinal prospective cohort of children with juvenile dermatomyositis (DM).METHODS: Children from 31 countries who were ages <18 years and had juvenile DM in active phase were studied, and analyses of height, weight, and pubertal development were conducted in those who had follow-up visits during a 2-year period and for whom anthropometric data was available.RESULTS: A total of 196 of 275 children (71%) were included. We found a significant reduction in parent-adjusted height Z score over time in female patients (P < 0.0001) and male patients (P = 0.001), but with catch-up growth at the final study visit. Median body mass index Z score peaked at 6 months (P < 0.0001) and was still significantly above baseline at the final study visit, which was at a median of 26 months after baseline (P = 0.007), with no difference between sexes. Female patients with a disease duration ≥12 months after onset had significantly lower parent-adjusted height Z score (P = 0.002) and no 2-year catch-up growth. At the final study visit, growth failure was seen in 20 of 97 female patients (21%) and in 11 of 73 male patients (15%). Height deflection (∆height Z score less than -0.25/year) was observed in 29 of 116 female patients (25%) and 25 of 80 male patients (31.3%). Delayed puberty was seen in 20 of 55 female patients (36.4%) and in 11 of 31 male patients (35.5%). Children in early pubertal stage at baseline had the highest risk of growth failure.CONCLUSION: Juvenile DM in the active phase and/or its treatment has a significant impact on growth and puberty in affected children. Children with recent onset of puberty or previous growth failure have the highest risk of delayed pubertal development and further growth retardation.

KW - Adolescent

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Dermatomyositis/diagnosis

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Puberty/physiology

U2 - 10.1002/acr.24065

DO - 10.1002/acr.24065

M3 - Journal article

VL - 72

SP - 265

EP - 273

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

IS - 2

ER -

ID: 58929472