Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Antinuclear Antibody-Negative Systemic Lupus Erythematosus in an International Inception Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Paediatric Rheumatology International Trials Organisation (PRINTO)
Vis graf over relationer

OBJECTIVES: To study growth and puberty in a multi-national longitudinal prospective cohort of juvenile dermatomyositis (JDM).

METHODS: Children with JDM ≤18 years in active phase from 31 countries were studied, analyzing height, weight and pubertal development in children with available anthropometric data and follow-up visits over two years.

RESULTS: A total of 196/275 (71%) children were included. We found a significant reduction in parent-adjusted height z score over time in females (p<0.0001) and males (p=0.001), but with catch-up growth at the final study visit. Median BMI z score peaked at 6 months (p<0.0001) and was still significantly above baseline at the final study visit at a median of 26 months (p=0.007) after baseline with no gender difference. Females with a disease duration ≥12 months after onset had significantly lower parent-adjusted height z score (p=0.002) and no 2-year catch-up growth. Growth failure was seen in 20 (21%) of the females and 11 (15%) of the males, at the final study visit. Height deflection (∆height z-score <-0.25/year) was observed in 29 (25%) of the females and 25 (31%) of the males. Delayed puberty was seen in 20/55 (36.4%) of the females and in 11/31 (35.5%) of the males. Children in early pubertal stage at baseline had the highest risk of growth failure.

CONCLUSIONS: JDM and/or its treatment has a significant impact on growth and puberty in the active phase in affected children. Children with recent onset of puberty or previous growth failure, have the highest risk of delayed pubertal development and further growth retardation.

OriginalsprogEngelsk
TidsskriftArthritis Care & Research
ISSN2151-464X
DOI
StatusE-pub ahead of print - 2020

Bibliografisk note

© 2019, American College of Rheumatology.

ID: 58929472