Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Complementary roles of intracellular and pericellular collagen degradation pathways in vivo

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Percutaneous coronary and structural interventions in women: a position statement from the EAPCI Women Committee

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The invisible army of women in interventional cardiology: EAPCI Women mission to make them visible

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Managerial strategies and policies - Analysis of patient satisfaction based on demographic data

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The influence of digital media on the success of a health care unit

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Giselle A Joseph
  • Min Lu
  • Maria Radu
  • Jennifer K Lee
  • Steven J Burden
  • Jonathan Chernoff
  • Robert S Krauss
Vis graf over relationer

Skeletal myogenesis is regulated by signal transduction, but the factors and mechanisms involved are not well understood. The group I Paks Pak1 and Pak2 are related protein kinases and direct effectors of Cdc42 and Rac1. Group I Paks are ubiquitously expressed and specifically required for myoblast fusion in Drosophila We report that both Pak1 and Pak2 are activated during mammalian myoblast differentiation. One pathway of activation is initiated by N-cadherin ligation and involves the cadherin coreceptor Cdo with its downstream effector, Cdc42. Individual genetic deletion of Pak1 and Pak2 in mice has no overt effect on skeletal muscle development or regeneration. However, combined muscle-specific deletion of Pak1 and Pak2 results in reduced muscle mass and a higher proportion of myofibers with a smaller cross-sectional area. This phenotype is exacerbated after repair to acute injury. Furthermore, primary myoblasts lacking Pak1 and Pak2 display delayed expression of myogenic differentiation markers and myotube formation. These results identify Pak1 and Pak2 as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad/Cdo/Cdc42 signaling pathway.

OriginalsprogEngelsk
TidsskriftMolecular and Cellular Biology
Vol/bind37
Udgave nummer4
Sider (fra-til)e00222-16
ISSN0270-7306
DOI
StatusUdgivet - 15 feb. 2017

ID: 52686104