Graduated elastic compression stockings in the prevention of post-thrombotic syndrome: A systematic review and meta-analysis

Jørn Dalsgaard Nielsen, Thomas Steffen Hermann, Pernille Cecilie Ammundsen Fredskilde

Abstract

BACKGROUND: The effect of graduated elastic compression stockings (ECS) in the prevention of post-thrombotic syndrome (PTS) has been questioned since a large randomized trial found no prophylactic effect of ECS.

OBJECTIVE: To assess the effect of the wearing time of ECS on the incidence of post-thrombotic syndrome (PTS) after proximal deep venous thrombosis, we performed a meta-analysis of the incidence of PTS across randomized and observational studies.

METHOD: PubMed, Embase and Cochrane databases were searched until 12 June 2023 for studies on the effect of ECS on PTS. References of eligible studies were also screened in order to identify other potential studies that might have been missed during the search.

RESULTS: Four studies comprising a total of 1467 patients met our inclusion criteria for early initiation and consistent use of ECS in patients with acute proximal DVT. ECS significantly reduced the incidence of mild-moderate PTS (OR: 0.48; 95% CI: 0.36-0.63) as well as severe PTS (OR: 0.44; 95% CI: 0.28-0.58).

OriginalsprogEngelsk
TidsskriftPhlebology
Vol/bind39
Udgave nummer4
Sider (fra-til)229-237
Antal sider9
ISSN1433-3031
DOI
StatusUdgivet - maj 2024

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