Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout

David Bursill; William J Taylor; Robert Terkeltaub; Abhishek Abhishek; Alexander K So; Ana Beatriz Vargas-Santos; Angelo Lino Gaffo; Ann Rosenthal; Anne-Kathrin Tausche; Anthony Reginato; Bernhard Manger; Carlo Sciré; Carlos Pineda; Caroline van Durme; Ching-Tsai Lin; Congcong Yin; Daniel Arthur Albert; Edyta Biernat-Kaluza; Edward Roddy; Eliseo Pascual; Fabio Becce; Fernando Perez-Ruiz; Francisca Sivera; Frédéric Lioté; Georg Schett; George Nuki; Georgios Filippou; Geraldine McCarthy; Geraldo da Rocha Castelar Pinheiro; Hang-Korng Ea; Helena De Almeida Tupinambá; Hisashi Yamanaka; Hyon K Choi; James Mackay; James R ODell; Janitzia Vázquez Mellado; Jasvinder A Singh; John D Fitzgerald; Lennart T H Jacobsson; Leo Joosten; Leslie R Harrold; Lisa Stamp; Mariano Andrés; Marwin Gutierrez; Masanari Kuwabara; Mats Dehlin; Matthijs Janssen; Michael Doherty; Michael S Hershfield; Michael Pillinger; N Lawrence Edwards; Naomi Schlesinger; Nitin Kumar; Ole Slot; Sebastien Ottaviani; Pascal Richette; Paul A MacMullan; Peter T Chapman; Peter E Lipsky; Philip Robinson; Puja P Khanna; Rada N Gancheva; Rebecca Grainger; Richard J Johnson; Ritch Te Kampe; Robert T Keenan; Sara K Tedeschi; Seoyoung Kim; Sung Jae Choi; Theodore R Fields; Thomas Bardin; Till Uhlig; Tim Jansen; Tony Merriman; Tristan Pascart; Tuhina Neogi; Viola Klück; Worawit Louthrenoo; Nicola Dalbeth

doi:10.1136/annrheumdis-2019-215933

Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout

David Bursill, William J Taylor, Robert Terkeltaub, Abhishek Abhishek, Alexander K So, Ana Beatriz Vargas-Santos, Angelo Lino Gaffo, Ann Rosenthal, Anne-Kathrin Tausche, Anthony Reginato, Bernhard Manger, Carlo Sciré, Carlos Pineda, Caroline van Durme, Ching-Tsai Lin, Congcong Yin, Daniel Arthur Albert, Edyta Biernat-Kaluza, Edward Roddy, Eliseo PascualFabio Becce, Fernando Perez-Ruiz, Francisca Sivera, Frédéric Lioté, Georg Schett, George Nuki, Georgios Filippou, Geraldine McCarthy, Geraldo da Rocha Castelar Pinheiro, Hang-Korng Ea, Helena De Almeida Tupinambá, Hisashi Yamanaka, Hyon K Choi, James Mackay, James R ODell, Janitzia Vázquez Mellado, Jasvinder A Singh, John D Fitzgerald, Lennart T H Jacobsson, Leo Joosten, Leslie R Harrold, Lisa Stamp, Mariano Andrés, Marwin Gutierrez, Masanari Kuwabara, Mats Dehlin, Matthijs Janssen, Michael Doherty, Michael S Hershfield, Michael Pillinger, N Lawrence Edwards, Naomi Schlesinger, Nitin Kumar, Ole Slot, Sebastien Ottaviani, Pascal Richette, Paul A MacMullan, Peter T Chapman, Peter E Lipsky, Philip Robinson, Puja P Khanna, Rada N Gancheva, Rebecca Grainger, Richard J Johnson, Ritch Te Kampe, Robert T Keenan, Sara K Tedeschi, Seoyoung Kim, Sung Jae Choi, Theodore R Fields, Thomas Bardin, Till Uhlig, Tim Jansen, Tony Merriman, Tristan Pascart, Tuhina Neogi, Viola Klück, Worawit Louthrenoo, Nicola Dalbeth

Afdeling for Rygkirurgi, Led- og Bindevævssygdomme

Abstract

OBJECTIVE: There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.

METHODS: A content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions.

RESULTS: The content analysis identified 13 unique disease states and a total of 63 unique labels. The Delphi exercise (n=76 respondents) and face-to-face meeting (n=35 attendees) established consensus agreement for eight disease state labels and definitions. The agreed labels were as follows: 'asymptomatic hyperuricaemia', 'asymptomatic monosodium urate crystal deposition', 'asymptomatic hyperuricaemia with monosodium urate crystal deposition', 'gout', 'tophaceous gout', 'erosive gout', 'first gout flare' and 'recurrent gout flares'. There was consensus agreement that the label 'gout' should be restricted to current or prior clinically evident disease caused by monosodium urate crystal deposition (gout flare, chronic gouty arthritis or subcutaneous tophus).

CONCLUSION: Consensus agreement has been established for the labels and definitions of eight gout disease states, including 'gout' itself. The Gout, Hyperuricaemia and Crystal-Associated Disease Network recommends the use of these labels when describing disease states of gout in research and clinical practice.

Originalsprog	Engelsk
Tidsskrift	Annals of the Rheumatic Diseases
Vol/bind	78
Udgave nummer	11
Sider (fra-til)	1592-1600
Antal sider	9
ISSN	0003-4967
DOI	https://doi.org/10.1136/annrheumdis-2019-215933
Status	Udgivet - nov. 2019

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10.1136/annrheumdis-2019-215933

Citationsformater

Bursill, D., Taylor, W. J., Terkeltaub, R., Abhishek, A., So, A. K., Vargas-Santos, A. B., Gaffo, A. L., Rosenthal, A., Tausche, A.-K., Reginato, A., Manger, B., Sciré, C., Pineda, C., van Durme, C., Lin, C.-T., Yin, C., Albert, D. A., Biernat-Kaluza, E., Roddy, E., ... Dalbeth, N. (2019). Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. Annals of the Rheumatic Diseases, 78(11), 1592-1600. https://doi.org/10.1136/annrheumdis-2019-215933

Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. / Bursill, David; Taylor, William J; Terkeltaub, Robert et al.
I: Annals of the Rheumatic Diseases, Bind 78, Nr. 11, 11.2019, s. 1592-1600.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Bursill, D, Taylor, WJ, Terkeltaub, R, Abhishek, A, So, AK, Vargas-Santos, AB, Gaffo, AL, Rosenthal, A, Tausche, A-K, Reginato, A, Manger, B, Sciré, C, Pineda, C, van Durme, C, Lin, C-T, Yin, C, Albert, DA, Biernat-Kaluza, E, Roddy, E, Pascual, E, Becce, F, Perez-Ruiz, F, Sivera, F, Lioté, F, Schett, G, Nuki, G, Filippou, G, McCarthy, G, da Rocha Castelar Pinheiro, G, Ea, H-K, Tupinambá, HDA, Yamanaka, H, Choi, HK, Mackay, J, ODell, JR, Vázquez Mellado, J, Singh, JA, Fitzgerald, JD, Jacobsson, LTH, Joosten, L, Harrold, LR, Stamp, L, Andrés, M, Gutierrez, M, Kuwabara, M, Dehlin, M, Janssen, M, Doherty, M, Hershfield, MS, Pillinger, M, Edwards, NL, Schlesinger, N, Kumar, N, Slot, O, Ottaviani, S, Richette, P, MacMullan, PA, Chapman, PT, Lipsky, PE, Robinson, P, Khanna, PP, Gancheva, RN, Grainger, R, Johnson, RJ, Te Kampe, R, Keenan, RT, Tedeschi, SK, Kim, S, Choi, SJ, Fields, TR, Bardin, T, Uhlig, T, Jansen, T, Merriman, T, Pascart, T, Neogi, T, Klück, V, Louthrenoo, W & Dalbeth, N 2019, 'Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout', Annals of the Rheumatic Diseases, bind 78, nr. 11, s. 1592-1600. https://doi.org/10.1136/annrheumdis-2019-215933

@article{09f6a9bbcdfb4541b9487b0c22e98150,

title = "Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout",

abstract = "OBJECTIVE: There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.METHODS: A content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions.RESULTS: The content analysis identified 13 unique disease states and a total of 63 unique labels. The Delphi exercise (n=76 respondents) and face-to-face meeting (n=35 attendees) established consensus agreement for eight disease state labels and definitions. The agreed labels were as follows: 'asymptomatic hyperuricaemia', 'asymptomatic monosodium urate crystal deposition', 'asymptomatic hyperuricaemia with monosodium urate crystal deposition', 'gout', 'tophaceous gout', 'erosive gout', 'first gout flare' and 'recurrent gout flares'. There was consensus agreement that the label 'gout' should be restricted to current or prior clinically evident disease caused by monosodium urate crystal deposition (gout flare, chronic gouty arthritis or subcutaneous tophus).CONCLUSION: Consensus agreement has been established for the labels and definitions of eight gout disease states, including 'gout' itself. The Gout, Hyperuricaemia and Crystal-Associated Disease Network recommends the use of these labels when describing disease states of gout in research and clinical practice.",

author = "David Bursill and Taylor, {William J} and Robert Terkeltaub and Abhishek Abhishek and So, {Alexander K} and Vargas-Santos, {Ana Beatriz} and Gaffo, {Angelo Lino} and Ann Rosenthal and Anne-Kathrin Tausche and Anthony Reginato and Bernhard Manger and Carlo Scir{\'e} and Carlos Pineda and {van Durme}, Caroline and Ching-Tsai Lin and Congcong Yin and Albert, {Daniel Arthur} and Edyta Biernat-Kaluza and Edward Roddy and Eliseo Pascual and Fabio Becce and Fernando Perez-Ruiz and Francisca Sivera and Fr{\'e}d{\'e}ric Liot{\'e} and Georg Schett and George Nuki and Georgios Filippou and Geraldine McCarthy and {da Rocha Castelar Pinheiro}, Geraldo and Hang-Korng Ea and Tupinamb{\'a}, {Helena De Almeida} and Hisashi Yamanaka and Choi, {Hyon K} and James Mackay and ODell, {James R} and {V{\'a}zquez Mellado}, Janitzia and Singh, {Jasvinder A} and Fitzgerald, {John D} and Jacobsson, {Lennart T H} and Leo Joosten and Harrold, {Leslie R} and Lisa Stamp and Mariano Andr{\'e}s and Marwin Gutierrez and Masanari Kuwabara and Mats Dehlin and Matthijs Janssen and Michael Doherty and Hershfield, {Michael S} and Michael Pillinger and Edwards, {N Lawrence} and Naomi Schlesinger and Nitin Kumar and Ole Slot and Sebastien Ottaviani and Pascal Richette and MacMullan, {Paul A} and Chapman, {Peter T} and Lipsky, {Peter E} and Philip Robinson and Khanna, {Puja P} and Gancheva, {Rada N} and Rebecca Grainger and Johnson, {Richard J} and {Te Kampe}, Ritch and Keenan, {Robert T} and Tedeschi, {Sara K} and Seoyoung Kim and Choi, {Sung Jae} and Fields, {Theodore R} and Thomas Bardin and Till Uhlig and Tim Jansen and Tony Merriman and Tristan Pascart and Tuhina Neogi and Viola Kl{\"u}ck and Worawit Louthrenoo and Nicola Dalbeth",

note = "COPECARE",

year = "2019",

month = nov,

doi = "10.1136/annrheumdis-2019-215933",

language = "English",

volume = "78",

pages = "1592--1600",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

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TY - JOUR

T1 - Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout

AU - Bursill, David

AU - Taylor, William J

AU - Terkeltaub, Robert

AU - Abhishek, Abhishek

AU - So, Alexander K

AU - Vargas-Santos, Ana Beatriz

AU - Gaffo, Angelo Lino

AU - Rosenthal, Ann

AU - Tausche, Anne-Kathrin

AU - Reginato, Anthony

AU - Manger, Bernhard

AU - Sciré, Carlo

AU - Pineda, Carlos

AU - van Durme, Caroline

AU - Lin, Ching-Tsai

AU - Yin, Congcong

AU - Albert, Daniel Arthur

AU - Biernat-Kaluza, Edyta

AU - Roddy, Edward

AU - Pascual, Eliseo

AU - Becce, Fabio

AU - Perez-Ruiz, Fernando

AU - Sivera, Francisca

AU - Lioté, Frédéric

AU - Schett, Georg

AU - Nuki, George

AU - Filippou, Georgios

AU - McCarthy, Geraldine

AU - da Rocha Castelar Pinheiro, Geraldo

AU - Ea, Hang-Korng

AU - Tupinambá, Helena De Almeida

AU - Yamanaka, Hisashi

AU - Choi, Hyon K

AU - Mackay, James

AU - ODell, James R

AU - Vázquez Mellado, Janitzia

AU - Singh, Jasvinder A

AU - Fitzgerald, John D

AU - Jacobsson, Lennart T H

AU - Joosten, Leo

AU - Harrold, Leslie R

AU - Stamp, Lisa

AU - Andrés, Mariano

AU - Gutierrez, Marwin

AU - Kuwabara, Masanari

AU - Dehlin, Mats

AU - Janssen, Matthijs

AU - Doherty, Michael

AU - Hershfield, Michael S

AU - Pillinger, Michael

AU - Edwards, N Lawrence

AU - Schlesinger, Naomi

AU - Kumar, Nitin

AU - Slot, Ole

AU - Ottaviani, Sebastien

AU - Richette, Pascal

AU - MacMullan, Paul A

AU - Chapman, Peter T

AU - Lipsky, Peter E

AU - Robinson, Philip

AU - Khanna, Puja P

AU - Gancheva, Rada N

AU - Grainger, Rebecca

AU - Johnson, Richard J

AU - Te Kampe, Ritch

AU - Keenan, Robert T

AU - Tedeschi, Sara K

AU - Kim, Seoyoung

AU - Choi, Sung Jae

AU - Fields, Theodore R

AU - Bardin, Thomas

AU - Uhlig, Till

AU - Jansen, Tim

AU - Merriman, Tony

AU - Pascart, Tristan

AU - Neogi, Tuhina

AU - Klück, Viola

AU - Louthrenoo, Worawit

AU - Dalbeth, Nicola

N1 - COPECARE

PY - 2019/11

Y1 - 2019/11

N2 - OBJECTIVE: There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.METHODS: A content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions.RESULTS: The content analysis identified 13 unique disease states and a total of 63 unique labels. The Delphi exercise (n=76 respondents) and face-to-face meeting (n=35 attendees) established consensus agreement for eight disease state labels and definitions. The agreed labels were as follows: 'asymptomatic hyperuricaemia', 'asymptomatic monosodium urate crystal deposition', 'asymptomatic hyperuricaemia with monosodium urate crystal deposition', 'gout', 'tophaceous gout', 'erosive gout', 'first gout flare' and 'recurrent gout flares'. There was consensus agreement that the label 'gout' should be restricted to current or prior clinically evident disease caused by monosodium urate crystal deposition (gout flare, chronic gouty arthritis or subcutaneous tophus).CONCLUSION: Consensus agreement has been established for the labels and definitions of eight gout disease states, including 'gout' itself. The Gout, Hyperuricaemia and Crystal-Associated Disease Network recommends the use of these labels when describing disease states of gout in research and clinical practice.

AB - OBJECTIVE: There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.METHODS: A content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions.RESULTS: The content analysis identified 13 unique disease states and a total of 63 unique labels. The Delphi exercise (n=76 respondents) and face-to-face meeting (n=35 attendees) established consensus agreement for eight disease state labels and definitions. The agreed labels were as follows: 'asymptomatic hyperuricaemia', 'asymptomatic monosodium urate crystal deposition', 'asymptomatic hyperuricaemia with monosodium urate crystal deposition', 'gout', 'tophaceous gout', 'erosive gout', 'first gout flare' and 'recurrent gout flares'. There was consensus agreement that the label 'gout' should be restricted to current or prior clinically evident disease caused by monosodium urate crystal deposition (gout flare, chronic gouty arthritis or subcutaneous tophus).CONCLUSION: Consensus agreement has been established for the labels and definitions of eight gout disease states, including 'gout' itself. The Gout, Hyperuricaemia and Crystal-Associated Disease Network recommends the use of these labels when describing disease states of gout in research and clinical practice.

U2 - 10.1136/annrheumdis-2019-215933

DO - 10.1136/annrheumdis-2019-215933

M3 - Journal article

C2 - 31501138

SN - 0003-4967

VL - 78

SP - 1592

EP - 1600

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 11

ER -

Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout

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