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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Improving the maturation rate of human oocytes collected ex vivo during the cryopreservation of ovarian tissue

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  2. Ovarian cortical follicle density in infertile women with low anti-Müllerian hormone

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  4. Cryopreservation of ovarian tissue may be considered in young girls with galactosemia

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  1. Expression of the Insulin-like Growth Factor System in First- and Second-Trimester Human Embryonic and Fetal Gonads

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Shortcomings of an unphysiological triggering of oocyte maturation using human chorionic gonadotropin

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  3. Surrogate testes: Allogeneic spermatogonial stem cell transplantation within an encapsulation device may restore male fertility

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  4. Effect of sphingosine-1-phosphate on activation of dormant follicles in murine and human ovarian tissue

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Vis graf over relationer

Purpose: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). Methods: A total of 665 women were consecutively enrolled for IVF during the period 2007–2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m2, non-smoking, regular menstruation cycle of 21–35 days, and bilateral ovaries. A blood sample was drawn for endocrine hormonal analysis and for DNA extraction with subsequent genotyping of the FSHR N680S and LHCGR N312S polymorphisms. Statistical analyses were done on all completed IVF cycles. Results: Women homozygous for S in both receptors combined (4S) had significantly higher live birth rate compared to those with other receptor variants when combining the first three IVF cycles (OR = 2.00, 95% CI [1.02, 3.92], p = 0.043). Cumulatively higher chance of live birth rate, during all IVF cycles, was also evident (HR = 1.89, 95% CI [1.00, 3.57], p = 0.049). Conclusions: Gonadotropin receptor variants are promising candidates for the prediction of the possibility to have a baby to take home after IVF treatment.

OriginalsprogEngelsk
TidsskriftJournal of Assisted Reproduction and Genetics
Vol/bind36
Udgave nummer1
Sider (fra-til)29-38
ISSN1058-0468
DOI
StatusUdgivet - 2019

ID: 55361055