Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Glycopyrrolate does not influence the visual or motor-induced increase in regional cerebral perfusion

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Dose of Bicarbonate to Maintain Plasma pH During Maximal Ergometer Rowing and Consequence for Plasma Volume

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Editorial: Advances in Rowing Physiology

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. Neuropeptides and the Nodes of Ranvier in Cranial Headaches

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Acetylcholine may contribute to the increase in regional cerebral blood flow (rCBF) during cerebral activation since glycopyrrolate, a potent inhibitor of acetylcholine, abolishes the exercise-induced increase in middle cerebral artery mean flow velocity. We tested the hypothesis that cholinergic vasodilatation is important for the increase in rCBF during cerebral activation. The subjects were 11 young healthy males at an age of 24 ± 3 years (mean ± SD). We used arterial spin labeling and blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) to evaluate rCBF with and without intravenous glycopyrrolate during a handgrip motor task and visual stimulation. Glycopyrrolate increased heart rate from 56 ± 9 to 114 ± 14 beats/min (mean ± SD; p < 0.001), mean arterial pressure from 86 ± 8 to 92 ± 12 mmHg, and cardiac output from 5.6 ± 1.4 to 8.0 ± 1.7 l/min. Glycopyrrolate had, however, no effect on the arterial spin labeling or BOLD responses to the handgrip motor task or to visual stimulation. This study indicates that during a handgrip motor task and visual stimulation, the increase in rCBF is unaffected by blockade of acetylcholine receptors by glycopyrrolate. Further studies on the effect of glycopyrrolate on middle cerebral artery diameter are needed to evaluate the influence of glycopyrrolate on mean flow velocity during intense exercise.

TidsskriftFrontiers in Physiology
Sider (fra-til)45
StatusUdgivet - 2014

ID: 45081824