Glycemic Responses to Graded Exercise Testing in Adolescents Using Automated Insulin Delivery Systems

Emilie Bundgaard Lindkvist; Olivia Mary McCarthy; Sandra Tawfik; Michael Zaucha Sørensen; Richard Bracken; Ajenthen G Ranjan; Jannet Svensson; Kirsten Nørgaard

doi:10.1177/15209156251390834

Glycemic Responses to Graded Exercise Testing in Adolescents Using Automated Insulin Delivery Systems

Emilie Bundgaard Lindkvist^*, Olivia Mary McCarthy, Sandra Tawfik, Michael Zaucha Sørensen, Richard Bracken, Ajenthen G Ranjan, Jannet Svensson, Kirsten Nørgaard

^*Corresponding author af dette arbejde

Steno Diabetes Center Copenhagen

Abstract

This study evaluated the glycemic responses to a graded exercise test (GXT) performed by 24 adolescents with type 1 diabetes (T1D) using automated insulin delivery (AID) systems. Each participant partook in a GXT on a bicycle ergometer until volitional exhaustion. Plasma glucose and lactate levels were measured during the GXT, whereas sensor glucose was monitored in the hours thereafter. Plasma glucose levels were stable throughout the GXT (overall change of -0.26 mmol/L [-5 mg/dL], P = 0.593), with no hypoglycemic events. Sensor glucose levels also remained stable and within the recommended glucose target ranges after the GXT for the remaining day and night, with only a few episodes of mild hypoglycemia. This study highlights the glycemic safety of performing GXT for adolescents utilizing AID systems.

Originalsprog	Engelsk
Tidsskrift	Diabetes Technology & Therapeutics
ISSN	1520-9156
DOI	https://doi.org/10.1177/15209156251390834
Status	Udgivet - 7 nov. 2025

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10.1177/15209156251390834Licens: Ikke-specificeret

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abstract = "This study evaluated the glycemic responses to a graded exercise test (GXT) performed by 24 adolescents with type 1 diabetes (T1D) using automated insulin delivery (AID) systems. Each participant partook in a GXT on a bicycle ergometer until volitional exhaustion. Plasma glucose and lactate levels were measured during the GXT, whereas sensor glucose was monitored in the hours thereafter. Plasma glucose levels were stable throughout the GXT (overall change of -0.26 mmol/L [-5 mg/dL], P = 0.593), with no hypoglycemic events. Sensor glucose levels also remained stable and within the recommended glucose target ranges after the GXT for the remaining day and night, with only a few episodes of mild hypoglycemia. This study highlights the glycemic safety of performing GXT for adolescents utilizing AID systems.",

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T1 - Glycemic Responses to Graded Exercise Testing in Adolescents Using Automated Insulin Delivery Systems

AU - Lindkvist, Emilie Bundgaard

AU - McCarthy, Olivia Mary

AU - Tawfik, Sandra

AU - Zaucha Sørensen, Michael

AU - Bracken, Richard

AU - Ranjan, Ajenthen G

AU - Svensson, Jannet

AU - Nørgaard, Kirsten

PY - 2025/11/7

Y1 - 2025/11/7

N2 - This study evaluated the glycemic responses to a graded exercise test (GXT) performed by 24 adolescents with type 1 diabetes (T1D) using automated insulin delivery (AID) systems. Each participant partook in a GXT on a bicycle ergometer until volitional exhaustion. Plasma glucose and lactate levels were measured during the GXT, whereas sensor glucose was monitored in the hours thereafter. Plasma glucose levels were stable throughout the GXT (overall change of -0.26 mmol/L [-5 mg/dL], P = 0.593), with no hypoglycemic events. Sensor glucose levels also remained stable and within the recommended glucose target ranges after the GXT for the remaining day and night, with only a few episodes of mild hypoglycemia. This study highlights the glycemic safety of performing GXT for adolescents utilizing AID systems.

AB - This study evaluated the glycemic responses to a graded exercise test (GXT) performed by 24 adolescents with type 1 diabetes (T1D) using automated insulin delivery (AID) systems. Each participant partook in a GXT on a bicycle ergometer until volitional exhaustion. Plasma glucose and lactate levels were measured during the GXT, whereas sensor glucose was monitored in the hours thereafter. Plasma glucose levels were stable throughout the GXT (overall change of -0.26 mmol/L [-5 mg/dL], P = 0.593), with no hypoglycemic events. Sensor glucose levels also remained stable and within the recommended glucose target ranges after the GXT for the remaining day and night, with only a few episodes of mild hypoglycemia. This study highlights the glycemic safety of performing GXT for adolescents utilizing AID systems.

U2 - 10.1177/15209156251390834

DO - 10.1177/15209156251390834

M3 - Journal article

C2 - 41203257

SN - 1520-9156

JO - Diabetes Technology & Therapeutics

JF - Diabetes Technology & Therapeutics

ER -

Glycemic Responses to Graded Exercise Testing in Adolescents Using Automated Insulin Delivery Systems

Abstract

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