Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Gluten-free diet modulates inflammation in salivary glands and pancreatic islets

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Salivary microbiota and inflammation-related proteins in patients with psoriasis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prevalence, type distribution, and risk factors for oral HPV in Danish renal transplant recipients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Workshop of European task force on medication-related osteonecrosis of the jaw-Current challenges

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Intestinal permeability in type 1 diabetes: An updated comprehensive overview

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Antibiotic treatment during early childhood and risk of type 1 diabetes in children: A national birth cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Can a gluten-free diet be partly protective for COVID-19 infection?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Objectives
A lifelong gluten-free (GF) diet ameliorates autoimmune diabetes in non-obese diabetic (NOD) mice and most likely in humans. Besides diabetes, NOD mice develop focal sialadenitis, as seen in Sjögren's syndrome (SS). In humans, type 1 diabetes (T1D) is also linked to SS. Here, we investigated whether a lifelong GF diet influences the immune cell infiltration in the salivary glands and pancreatic islets in NOD mice.

Methods
NOD mice were fed a lifelong (i.e. 13 weeks) GF or gluten-containing standard (STD) diet. Insulitis and sialadenitis were scored on H&E-stained paraffin-embedded sections of pancreas and submandibular glands. Immune cell specificity and distribution were investigated immunohistochemically.

Results
There were fewer CD68+ and CD4+ cells in submandibular gland areas with focal sialadenitis as well as reduced insulitis and fewer VEGFR2+ cells in pancreatic islets in mice on GF versus STD diet. The degree of sialadenitis was not significantly lower in GF mice, but sialadenitis and insulitis correlated strongly. Lung weight was lower in GF mice.

Conclusion
In NOD mice, a lifelong GF diet reduces infiltration of monocytes/macrophages and T cells in salivary glands and inflammation in pancreatic islets, possibly by reducing VEGFR2, indicating that the linked autoimmune diseases, T1D and SS, may be alleviated by a GF diet.
OriginalsprogEngelsk
TidsskriftOral Diseases
Vol/bind28
Udgave nummer3
Sider (fra-til)639-647
Antal sider9
ISSN1354-523X
DOI
StatusUdgivet - apr. 2022

ID: 70287757