Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Different preprocessing strategies lead to different conclusions: A [11C]DASB-PET reproducibility study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Reference programme: diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 3rd edition, 2020

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Volume of hippocampal subregions and clinical improvement following electroconvulsive therapy in patients with depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Intradural artery dilation during experimentally induced migraine attacks

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Migraine is a complex disorder, involving peripheral and central brain structures, where mechanisms and site of attack initiation are an unresolved puzzle. While abnormal pontine neuronal activation during migraine attacks has been reported, exact implication of this finding is unknown. Evidence suggests an important role of glutamate in migraine, implying a possible association of pontine hyperactivity to increased glutamate levels. Migraine without aura patients were scanned during attacks after calcitonin gene-related peptide and sildenafil in a double-blind, randomized, double-dummy, cross-over design, on two separate study days, by proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling at 3T. Headache characteristics were recorded until 24 h after drug administrations. Twenty-six patients were scanned during migraine, yielding a total of 41 attacks. Cerebral blood flow increased in dorsolateral pons, ipsilateral to pain side during attacks, compared to outside attacks (13.6%, p = 0.009). Glutamate levels in the same area remained unchanged during attacks (p = 0.873), while total creatine levels increased (3.5%, p = 0.041). In conclusion, dorsolateral pontine activation during migraine was not associated with higher glutamate levels. However, the concurrently increased total creatine levels may suggest an altered energy metabolism, which should be investigated in future studies to elucidate the role of pons in acute migraine.

OriginalsprogEngelsk
TidsskriftJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Vol/bind41
Udgave nummer3
Sider (fra-til)604-616
Antal sider13
ISSN0271-678X
DOI
StatusUdgivet - mar. 2021

ID: 60054404