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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Glucose-induced thermogenesis in patients with small cell lung carcinoma. The effect of acute beta-adrenergic inhibition.

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  1. Gastrointestinal mean transit times in young and middle-aged healthy subjects.

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  2. Forearm metabolism during infusion of adrenaline: comparison of the dominant and non-dominant arm

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  3. Simplified scintigraphic methods for measuring gastrointestinal transit times.

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  4. Transperitoneal transport in diabetic and non-diabetic patients on peritoneal dialysis

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  2. Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1: a functional GLP-1-renal axis in man

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  3. Empagliflozin in heart failure patients with reduced ejection fraction: a randomized clinical trial (Empire HF)

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  4. GIP-induced vasodilation in human adipose tissue involves capillary recruitment

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  5. An acoustic myography functional assessment of cerebral palsy subjects compared to healthy controls during physical exercise

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Seven patients with histologically verified small cell lung carcinoma were given an oral glucose load of 75 g on two occasions to examine the effect of glucose on whole body and forearm thermogenesis with and without acute beta-adrenergic inhibition with propranolol. Whole body energy expenditure was measured by the open circuit ventilated hood system. Forearm blood flow was measured by venous occlusion strain-gauge plethysmography. The uptake of oxygen in the forearm was calculated as the product of the forearm blood flow and the difference in arteriovenous oxygen concentration. The glucose-induced thermogenesis in the 120 min following the glucose load was significantly reduced by beta-adrenergic inhibition with approximately 50% from 63.9 +/- 5.8 kJ 120 min-1 (mean +/- SE) to 27.8 +/- 9.8 kJ 120 min-1 (P <0.01). Almost the entire reduction took place from 60 to 120 min (P <0.005). The integrated glucose-induced forearm oxygen uptake in the period 60-120 min following the glucose load was significantly reduced after beta-adrenergic inhibition from 103 +/- 28 mumol 100 g-1 60 min-1 to 29 +/- 29 mumol 100 g-1 60 min-1 (P <0.05). The noreadrenaline concentration in the arterial blood was not increased in the baseline period compared to healthy elderly; it increased following the glucose load while there was no demonstrable increase in adrenaline concentration in the two experiments. It is suggested that these patients have increased sensitivity of the beta-adrenergic receptors and an early facultative component of the glucose-induced thermogenesis in part takes place in the forearm.
OriginalsprogEngelsk
TidsskriftClinical physiology (Oxford, England)
Vol/bind14
Udgave nummer5
Sider (fra-til)489-499
Antal sider11
ISSN0144-5979
StatusUdgivet - sep. 1994

ID: 32511603