Glucose recovery after intranasal glucagon during hypoglycaemia in man.

A Hvidberg, R Djurup, J Hilsted

    22 Citationer (Scopus)

    Abstrakt

    We compared the hyperglycaemic effect of intranasal and intramuscular (i.m.) administration of glucagon after insulin-induced hypoglycaemia. Twelve healthy subjects were examined twice, receiving on both occasions an intravenous insulin bolus. Somatostatin and propranolol were administered to block endogenous glucose counterregulation, and glucose turnover was estimated by a 3-[3H]-glucose infusion. When hypoglycaemia was reached, the subjects received either i.m. glucagon of pancreatic extraction (1 mg) or intranasal genetically engineered glucagon (2 mg). The incremental values for plasma glucose concentrations 15 min after intranasal and i.m. administration of glucagon differed marginally. However, after 5 min the glucose appearance rate, as well as the incremental values for plasma glucose, were significantly higher for the i.m. glucagon treatment. The mean time taken for incremental plasma glucose to exceed 3 mmol.l-1 was significantly shorter for i.m. glucagon. The mean plasma glucagon level increased faster after i.m. glucagon than after intranasal glucagon, and the levels remained higher throughout the study period. We conclude that glucose recovery was significantly better after i.m. administration of glucagon than after intranasal administration. However, the differences between the incremental plasma glucose and the time for incremental plasma glucose to exceed 3 mmol.l-1 were not considered of major clinical importance.
    OriginalsprogEngelsk
    TidsskriftEuropean Journal of Clinical Pharmacology
    Vol/bind46
    Udgave nummer1
    Sider (fra-til)15-17
    Antal sider3
    ISSN0031-6970
    StatusUdgivet - 1994

    Fingeraftryk

    Dyk ned i forskningsemnerne om 'Glucose recovery after intranasal glucagon during hypoglycaemia in man.'. Sammen danner de et unikt fingeraftryk.

    Citationsformater